K
Karim Brohi
Researcher at Queen Mary University of London
Publications - 222
Citations - 21180
Karim Brohi is an academic researcher from Queen Mary University of London. The author has contributed to research in topics: Coagulopathy & Major trauma. The author has an hindex of 55, co-authored 206 publications receiving 18216 citations. Previous affiliations of Karim Brohi include London's Air Ambulance & NHS Blood and Transplant.
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Journal ArticleDOI
Circulating mitochondrial DAMPs cause inflammatory responses to injury
Qin Zhang,Mustafa Raoof,Yu Chen,Yuka Sumi,Tolga Sursal,Wolfgang G. Junger,Karim Brohi,Kiyoshi Itagaki,Carl J. Hauser +8 more
TL;DR: It is shown that injury releases mitochondrial DAMPs into the circulation with functionally important immune consequences, including formyl peptides and mitochondrial DNA, which promote PMN Ca2+ flux and phosphorylation of mitogen-activated protein (MAP) kinases, thus leading to PMN migration and degranulation in vitro and in vivo.
Journal ArticleDOI
Acute traumatic coagulopathy.
TL;DR: There is a common and clinically important acute traumatic coagulopathy that is not related to fluid administration that is related to mortality and a coagulation screen is an important early test in severely injured patients.
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The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial.
Ian Roberts,Haleema Shakur,AO Afolabi,Karim Brohi,Timothy J Coats,Yashbir Dewan,Satoshi Gando,Gordon H. Guyatt,Beverley J. Hunt,Carlos Morales,Pablo Perel,David Prieto-Merino,Tom Woolley +12 more
TL;DR: Strong evidence is recorded that tranexamic acid should be given as early as possible to bleeding trauma patients with significant haemorrhage, and for trauma patients admitted late after injury, tranExamic acid is less effective and could be harmful.
Journal ArticleDOI
Acute traumatic coagulopathy.
TL;DR: Conventional concepts of traumatic coagulopathy as a late occurring condition in response to iatrogenic haemodilution are redundant and ATC is an endogenous impairment of haemostasis that begins at the moment of injury.
Journal ArticleDOI
The coagulopathy of trauma: a review of mechanisms.
John R. Hess,Karim Brohi,Richard P. Dutton,Carl J. Hauser,John B. Holcomb,Yoram Kluger,Kevin Mackway-Jones,Michael Parr,Sandro Rizoli,Tetsuo Yukioka,David B. Hoyt,Bertil Bouillon +11 more
TL;DR: There is limited understanding of the mechanisms by which tissue trauma, shock, and inflammation initiate trauma coagulopathy, and Acute Coagulopathic of Trauma-Shock should be considered distinct from disseminated intravascular coagulation as described in other conditions.