F
Federico Baldini
Researcher at University of Luxembourg
Publications - 12
Citations - 710
Federico Baldini is an academic researcher from University of Luxembourg. The author has contributed to research in topics: Microbiome & Metagenomics. The author has an hindex of 6, co-authored 10 publications receiving 372 citations. Previous affiliations of Federico Baldini include Columbia University.
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Journal ArticleDOI
BacArena: Individual-based metabolic modeling of heterogeneous microbes in complex communities
TL;DR: This study combinesconstraint-based and individual-based modeling techniques into the R package BacArena to generate novel biological insights into Pseudomonas aeruginosa biofilm formation as well as a seven species model community of the human gut.
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Systematic assessment of secondary bile acid metabolism in gut microbes reveals distinct metabolic capabilities in inflammatory bowel disease.
Almut Heinken,Dmitry A. Ravcheev,Federico Baldini,Laurent Heirendt,Ronan M. T. Fleming,Ines Thiele,Ines Thiele +6 more
TL;DR: This large-scale modeling approach provides a novel way of analyzing metagenomics data to accelerate the understanding of the metabolic interactions between the host and gut microbiomes in health and diseases states.
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Parkinson's disease-associated alterations of the gut microbiome predict disease-relevant changes in metabolic functions.
Federico Baldini,Johannes Hertel,Estelle Sandt,Cyrille C. Thinnes,Lorieza Neuberger-Castillo,Lukas Pavelka,Lukas Pavelka,Fay Betsou,Rejko Krüger,Rejko Krüger,Ines Thiele +10 more
TL;DR: PD-associated alterations of the gut microbiome can translate into substantial functional differences affecting host metabolism and disease phenotype, as suggested by an analysis of stool samples from the Luxembourg Parkinson’s Study.
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Integrated Analyses of Microbiome and Longitudinal Metabolome Data Reveal Microbial-Host Interactions on Sulfur Metabolism in Parkinson’s Disease
Johannes Hertel,Johannes Hertel,Johannes Hertel,Amy C. Harms,Almut Heinken,Almut Heinken,Federico Baldini,Cyrille C. Thinnes,Cyrille C. Thinnes,Enrico Glaab,Daniel A. Vasco,Maik Pietzner,Isobel D. Stewart,Nicholas J. Wareham,Claudia Langenberg,Claudia Trenkwalder,Rejko Krüger,Rejko Krüger,Thomas Hankemeier,Ronan M. T. Fleming,Ronan M. T. Fleming,Ronan M. T. Fleming,Brit Mollenhauer,Ines Thiele +23 more
TL;DR: The multi-omics integration reveals PD-specific patterns in microbial-host sulfur co-metabolism that may contribute to PD severity.
Journal ArticleDOI
The Microbiome Modeling Toolbox: from microbial interactions to personalized microbial communities
Federico Baldini,Almut Heinken,Laurent Heirendt,Stefania Magnusdottir,Ronan M. T. Fleming,Ronan M. T. Fleming,Ines Thiele +6 more
TL;DR: The Microbiome Modeling Toolbox extends the functionality of the constraint-based reconstruction and analysis toolbox to model (i) microbe– microbe and host–microbe metabolic interactions, and (ii) microbial communities using microbial genome-scale metabolic reconstructions and metagenomic data.