Showing papers in "EClinicalMedicine in 2020"

TL;DR: This retrospective cohort study retrospectively analyzed the clinical data of 34 patients underwent elective surgeries during the incubation period of COVID-19 at Renmin Hospital, Zhongnan Hospital, Tongji Hospital and Central Hospital in Wuhan from January 1 to February 5, 2020 to describe their clinical characteristics and outcomes.

TL;DR: There were noticeable demographic and geographical disparities in vaccine acceptance, and Black Americans reported lower influenza vaccine uptake and lower COVID-19 vaccine acceptance than all other racial groups reported in this study.

TL;DR: Radiological and physiological abnormalities were still found in a considerable proportion of COVID-19 survivors without critical cases 3 months after discharge, and higher level of D-dimer levels on admission could effectively predict impaired DLCO after 3 months discharge.

TL;DR: Mental health outcomes were statistically positively correlated with skin lesion and negatively correlated with self-efficacy, resilience, social support, and frontline work willingness, and future interventions at the national and organisational levels are needed.

TL;DR: Robust evidence from ongoing clinical trials is needed to determine the impact of thromboprophylaxis on TE and mortality risk of COVID-19.

TL;DR: In this series of seven COVID-19 autopsies, thrombosis was a prominent feature in multiple organs, in some cases despite full anticoagulation and regardless of timing of the disease course, suggesting that thROMbosis plays a role very early in the disease process.

TL;DR: Individuals from Black and Asian ethnicities are at increased risk of COVID-19 infection compared to White individuals; Asians may be at higher risk of ITU admission and death.

TL;DR: Emerging data from the grey literature and preprint articles suggest BAME individuals are at an increased risk of acquiring SARS-CoV-2 infection compared to White individuals and also worse clinical outcomes from COVID-19.

TL;DR: The global prevalence and incidence of knee OA varied substantially between individual countries and increased with age, and these findings can be used to better assess the global health burden of knees OA.

TL;DR: Evidence is provided that children diagnosed with COVID-19 have an overall excellent prognosis and future longitudinal studies are needed to confirm the findings and better understand which patients are at increased risk for developing severe inflammation and multiorgan failure.

TL;DR: The typical presentation and outcomes of children diagnosed with MIS-C are described, a new pediatric disease associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that is dangerous and potentially lethal.

TL;DR: Findings revealed possible disruption to micro-structural and functional brain integrity in the recovery stages of COVID-19, suggesting the long-term consequences of SARS-CoV-2.

TL;DR: This paper aims to demonstrate the efforts towards in-situ applicability of EMMARM, which aims to provide real-time information to policymakers and practitioners on how to promote and protect against infectious disease in the developing world.

TL;DR: In this exploratory analysis, low levels of national preparedness, scale of testing and population characteristics were associated with increased national case load and overall mortality.

TL;DR: The available evidence is reassuring, suggesting that maternal morbidity is similar to that of women of reproductive age, and vertical transmission of the virus probably occurs, albeit in a small proportion of cases.

TL;DR: Women and those who have more than 10 years of working, concomitant chronic diseases, history of mental disorders, and family members or relatives confirmed or suspected are susceptible to stress, depression and anxiety among HWs during the pandemic.

TL;DR: Black patients receiving ambulatory care at Bronx Montefiore Health System demonstrates that Blacks do have a higher mortality with COVID incompletely explained by age, multiple reported comorbidities and available metrics of sociodemographic disparity.

TL;DR: It is demonstrated how long term increases in TB burden could be averted in the short term through supplementary “catch-up” TB case detection and treatment, once restrictions are eased.

TL;DR: COVID-19 can affect the retina and mean arteries diameter and mean veins diameter seems directly correlated with the disease severity, and the influence of clinical/lab parameters on retinal findings was tested in CO VID-19 patients.

TL;DR: Impairment of spermatogenesis was observed in COVID-19 patients, which could be partially explained as a result of an elevated immune response in testis, and autoimmune orchitis occurred in some COVID -19 patients.

TL;DR: Implementing a universal facemask wearing policy in the whole of China could lead to severe facemasks shortage, and public health measures aimed at improving hand hygiene and effective public communication should be considered along with thefacemask policy.

TL;DR: The European RISC-19-ICU cohort demonstrates a moderate mortality of 24% in critically ill patients with COVID-19, and Elevated risk of bloodstream infections underscores the need to exercise caution with off-label therapies.

TL;DR: In patients with severe COVID-19, tocilizumab was associated with significantly shorter duration of vasopressor support and short duration of invasive ventilation, and these findings require validation from ongoing clinical trials of TocilIZumab in COVID–19 patients.

TL;DR: Patients with COVID-19 can be rapidly distinguished from patients with other conditions at first healthcare contact with near-patient gas chromatography-ion mobility spectrometry, and development and validation of this approach may allow rapid diagnosis of CO VID-19 in the coming endemic flu seasons.

TL;DR: It appears that the less rigid lockdown led to an insufficient decrease in mobility to reverse an outbreak such as COVID-19, and mobility decreased enough to bring down transmission promptly below the level needed to sustain the epidemic.

TL;DR: MSC therapy continues to exhibit a favourable safety profile and future trials should continue to strengthen study rigor, reporting of MSC characterization, and adverse events.

TL;DR: In a resource-constrained setting, HFNO for severe COVID-19 HRF is feasible and more almost half of those who receive it can be successfully weaned without the need for mechanical ventilation.

TL;DR: Age, diabetes, coronary heart disease (CHD), percentage of lymphocytes (LYM), procalcitonin (PCT), serum urea, C reactive protein and D-dimer (DD), were identified associated with mortality and identified as independent risk factors for mortality.

TL;DR: A subgroup of symptomatic SARS-CoV-2 positive patients (~5% of patients), who remained seronegative across a wide range of antigens, isotypes, and technologies are identified, suggesting that cross-reactive immunity from previous CoV strains is unlikely to explain the milder disease course in children.

TL;DR: The demographics, clinical manifestations, and outcomes in this unique patient population diagnosed with COVID-19 according to WHO guidelines and admitted to Jaber Al-Ahmad Al-Sabah Hospital were characterized.