F
Federico Lazzaro
Researcher at University of Milan
Publications - 30
Citations - 2272
Federico Lazzaro is an academic researcher from University of Milan. The author has contributed to research in topics: DNA repair & G2-M DNA damage checkpoint. The author has an hindex of 18, co-authored 30 publications receiving 2101 citations.
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The DNA Damage Checkpoint Response Requires Histone H2B Ubiquitination by Rad6-Bre1 and H3 Methylation by Dot1
TL;DR: It is demonstrated that ubiquitination of histone H2B on lysine 123 by the Rad6-Bre1 complex, is necessary for activation of Rad53 kinase and cell cycle arrest and results suggest that histone modifications may have a role in checkpoint function by modulating the interactions of Rad9 with chromatin and active Mec1 kinase.
Journal ArticleDOI
Mutations in the mitochondrial protease gene AFG3L2 cause dominant hereditary ataxia SCA28
Daniela Di Bella,Federico Lazzaro,Alfredo Brusco,Massimo Plumari,Giorgio Battaglia,Annalisa Pastore,Adele Finardi,Claudia Cagnoli,Filippo Tempia,Marina Frontali,Liana Veneziano,Tiziana Sacco,Enrica Boda,Alessandro Brussino,Florian Bonn,Barbara Castellotti,Silvia Baratta,Caterina Mariotti,Cinzia Gellera,Valentina Fracasso,Stefania Magri,Thomas Langer,Paolo Plevani,Stefano Di Donato,Marco Muzi-Falconi,Franco Taroni +25 more
TL;DR: This work identifies AFG3L2 as a novel cause of dominant neurodegenerative disease and indicates a previously unknown role for this component of the mitochondrial protein quality control machinery in protecting the human cerebellum against neurodegenersation.
Histone methyltransferase Dot1 and Rad9 inhibit single-stranded DNA accumulation at DSBs and uncapped telomeres This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits distribution, and reproduction in any medium, provided the original author and source are credited. This license does not permit commercial exploitation or the creation of derivative works without specific permission.
Federico Lazzaro,Vasileia Sapountzi,Granata M,Achille Pellicioli,Moreshwar B. Vaze,James E. Haber,Paolo Plevani,David Lydall,Marco Muzi-Falconi +8 more
TL;DR: It is suggested that both Rad9 and histone H3 methylation allow transmission of the damage signal to checkpoint kinases, and keep resection of damaged DNA under control influencing, both positively and negatively, checkpoint cascades and contributing to a tightly controlled response to DNA damage.
Journal ArticleDOI
Histone methyltransferase Dot1 and Rad9 inhibit single‐stranded DNA accumulation at DSBs and uncapped telomeres
Federico Lazzaro,Vasileia Sapountzi,Granata M,Achille Pellicioli,Moreshwar B. Vaze,James E. Haber,Paolo Plevani,David Lydall,Marco Muzi-Falconi +8 more
TL;DR: In this paper, Rad9 binding to histone H3-K79 methylated histone methylation has been shown to inhibit resection at DSBs and uncapped telomeres.
Journal ArticleDOI
RNase H and Postreplication Repair Protect Cells from Ribonucleotides Incorporated in DNA
Federico Lazzaro,Daniele Novarina,Flavio Amara,Danielle L. Watt,Jana E. Stone,Vincenzo Costanzo,Peter M. J. Burgers,Thomas A. Kunkel,Paolo Plevani,Marco Muzi-Falconi +9 more
TL;DR: It is demonstrated that postreplication repair pathways—MMS2-dependent template switch and Pol ζ-dependent bypass—are crucial for tolerating the presence of rNMPs in the chromosomes, and may be relevant for the pathogenesis of Aicardi-Goutières syndrome.