F
Felicia F. Chen
Researcher at University of Michigan
Publications - 15
Citations - 9083
Felicia F. Chen is an academic researcher from University of Michigan. The author has contributed to research in topics: NOD2 & Pyrin domain. The author has an hindex of 14, co-authored 15 publications receiving 8797 citations.
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Journal ArticleDOI
A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
Yasunori Ogura,Denise K. Bonen,Naohiro Inohara,Dan L. Nicolae,Felicia F. Chen,Richard Ramos,Heidi M. Britton,Thomas M. Moran,Reda Karaliuskas,Richard H. Duerr,Jean-Paul Achkar,Steven R. Brant,Theodore M. Bayless,Barbara S. Kirschner,Stephen B. Hanauer,Gabriel Núñez,Judy H. Cho +16 more
TL;DR: It is shown that a frameshift mutation caused by a cytosine insertion, 3020insC, which is expected to encode a truncated NOD2 protein, is associated with Crohn's disease, and a link between an innate immune response to bacterial components and development of disease is suggested.
Journal ArticleDOI
Nod2, a Nod1/Apaf-1 Family Member That Is Restricted to Monocytes and Activates NF-κB *
Yasunori Ogura,Naohiro Inohara,Adalberto Benito,Felicia F. Chen,Shoji Yamaoka,Shoji Yamaoka,Gabriel Núñez +6 more
TL;DR: A subfamily of Apaf-1-like proteins that function through RICK to activate a NF-κB signaling pathway is defined, which contains a caspase recruitment domain linked to a nucleotide-binding domain and multiple C-terminal leucine-rich repeats.
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An Induced Proximity Model for NF-κB Activation in the Nod1/RICK and RIP Signaling Pathways
Naohiro Inohara,Takeyoshi Koseki,Jingmei Lin,Luis del Peso,Peter C. Lucas,Felicia F. Chen,Yasunori Ogura,Gabriel Núñez +7 more
TL;DR: The proximity of RICK, RIP, and IKK complexes may play an important role for NF-kappaB activation during Nod1 oligomerization or trimerization of the tumor necrosis factor alpha receptor.
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Human Nod1 confers responsiveness to bacterial lipopolysaccharides.
TL;DR: It is shown that bacterial lipopolysaccharides, but not other pathogen components tested, induced TLR4- and MyD88-independent NF-κB activation in human embryonic kidney 293T cells expressing trace amounts of Nod 1, suggesting that Nod1 and Nod2 are mammalian counterparts of plant disease-resistant gene products that may function as cytosolic receptors for pathogen component derived from invading bacteria.
Journal ArticleDOI
Expression of NOD2 in Paneth cells: a possible link to Crohn's ileitis.
Yasunori Ogura,S. Lala,Wei Xin,Elizabeth Smith,Theresa A Dowds,Felicia F. Chen,Ellen M. Zimmermann,Maria Tretiakova,Judy H. Cho,John Hart,Joel K. Greenson,Satish Keshav,Gabriel Núñez +12 more
TL;DR: A role for NOD2 in the regulation of Paneth cell mediated responses against intestinal bacteria is suggested and a plausible mechanism to explain the selective association of N OD2 mutations with ileal disease is suggested.