Felicia F. Chen

TL;DR: Functional studies revealed that the G908R, R702W, and L1007fsinsC variants in the presence and absence of P268S are defective in their ability to respond to bacterial LPS and PGN, whereas P 268S alone exhibited wild-type activity.

TL;DR: It is reported that co-expression of ASC with Ipaf or oligomerization of ASC induces both apoptosis and NF-kappa B activation and Caspase-8-dependent apoptosis in an IpAF signaling pathway.

TL;DR: It is suggested that Bimp1 links surface receptor stimulation and protein kinase C activation to Bcl10/MALT1, thus leading to NF-κB induction.

TL;DR: It is found that Nod2-dependent activation of NF-κB and cytokine secretion is inhibited by Erbin overexpression, whereas Erbin-/- mouse embryo fibroblasts show an increased sensitivity to muramyl dipeptide.

TL;DR: It is reported here that co-expression of cryopyrin with its binding partner, ASC, induced both apoptosis and NF-kappaB activation, and this signaling was mimicked by oligomerization of ASC, suggesting that cryopyrsin activates downstream targets as reported for other Nod family members.