Y
Yasunori Ogura
Researcher at Nara Women's University
Publications - 53
Citations - 20692
Yasunori Ogura is an academic researcher from Nara Women's University. The author has contributed to research in topics: NOD2 & Innate immune system. The author has an hindex of 36, co-authored 53 publications receiving 19774 citations. Previous affiliations of Yasunori Ogura include Yale University & University of Michigan.
Papers
More filters
Journal ArticleDOI
A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
Yasunori Ogura,Denise K. Bonen,Naohiro Inohara,Dan L. Nicolae,Felicia F. Chen,Richard Ramos,Heidi M. Britton,Thomas M. Moran,Reda Karaliuskas,Richard H. Duerr,Jean-Paul Achkar,Steven R. Brant,Theodore M. Bayless,Barbara S. Kirschner,Stephen B. Hanauer,Gabriel Núñez,Judy H. Cho +16 more
TL;DR: It is shown that a frameshift mutation caused by a cytosine insertion, 3020insC, which is expected to encode a truncated NOD2 protein, is associated with Crohn's disease, and a link between an innate immune response to bacterial components and development of disease is suggested.
Journal ArticleDOI
Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract.
Koichi Kobayashi,Mathias Chamaillard,Yasunori Ogura,Octavian Henegariu,Naohiro Inohara,Gabriel Núñez,Richard A. Flavell +6 more
TL;DR: It is shown that protective immunity mediated by Nod2 recognition of bacterial muramyl dipeptide is abolished in Nod1-deficient mice, providing a possible mechanism for Nod 2 mutations in CD.
Journal ArticleDOI
Host Recognition of Bacterial Muramyl Dipeptide Mediated through NOD2 IMPLICATIONS FOR CROHN′S DISEASE
Naohiro Inohara,Yasunori Ogura,Ana Fontalba,Olga Gutierrez,F. Pons,Javier Crespo,Koichi Fukase,Seiichi Inamura,Shoichi Kusumoto,Masahito Hashimoto,Simon J. Foster,Anthony P. Moran,Jose L. Fernandez-Luna,Gabriel Núñez +13 more
TL;DR: NOD2 mediates the host response to bacterial muropeptides derived from peptidoglycan, an activity that is important for protection against Crohn's disease and has implications for understanding adjuvant function and effective vaccine development.
Journal ArticleDOI
Nod2, a Nod1/Apaf-1 Family Member That Is Restricted to Monocytes and Activates NF-κB *
Yasunori Ogura,Naohiro Inohara,Adalberto Benito,Felicia F. Chen,Shoji Yamaoka,Shoji Yamaoka,Gabriel Núñez +6 more
TL;DR: A subfamily of Apaf-1-like proteins that function through RICK to activate a NF-κB signaling pathway is defined, which contains a caspase recruitment domain linked to a nucleotide-binding domain and multiple C-terminal leucine-rich repeats.
Journal ArticleDOI
An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid.
Mathias Chamaillard,Masahito Hashimoto,Yasuo Horie,Junya Masumoto,Su Qiu,Lisa Saab,Yasunori Ogura,Akiko Kawasaki,Koichi Fukase,Shoichi Kusumoto,Miguel A. Valvano,Simon J. Foster,Tak W. Mak,Gabriel Núñez,Naohiro Inohara +14 more
TL;DR: It is reported that NOD1 mediates selective recognition of bacteria through detection of iE-DAP-containing peptidoglycan derived primarily from Gram-negative bacteria.