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Felicity D. Chandler
Researcher at Erasmus University Rotterdam
Publications - 15
Citations - 1887
Felicity D. Chandler is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Coronavirus & Serology. The author has an hindex of 7, co-authored 11 publications receiving 1362 citations. Previous affiliations of Felicity D. Chandler include Erasmus University Medical Center.
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Journal ArticleDOI
Severe Acute Respiratory Syndrome Coronavirus 2-Specific Antibody Responses in Coronavirus Disease Patients
Nisreen M.A. Okba,Marcel A. Müller,Wentao Li,Chunyan Wang,Corine H. GeurtsvanKessel,Victor M. Corman,Mart M. Lamers,Reina S. Sikkema,Erwin de Bruin,Felicity D. Chandler,Yazdan Yazdanpanah,Quentin Le Hingrat,Diane Descamps,Nadhira Houhou-Fidouh,Chantal B.E.M. Reusken,Berend Jan Bosch,Christian Drosten,Marion Koopmans,Bart L. Haagmans +18 more
TL;DR: It is demonstrated that most PCR-confirmed SARS-CoV-2–infected persons seroconverted by 2 weeks after disease onset, and validated and tested various antigens in different in-house and commercial ELISAs, finding that commercial S1 IgG or IgA ELISA were of lower specificity, and sensitivity varied between the 2 assays; the IgAELISA showed higher sensitivity.
Posted ContentDOI
SARS-CoV-2 specific antibody responses in COVID-19 patients
Nisreen M.A. Okba,Marcel A. Müller,Wentao Li,Chunyan Wang,Corine H. GeurtsvanKessel,Victor M. Corman,Mart M. Lamers,Reina S. Sikkema,Erwin de Bruin,Felicity D. Chandler,Yazdan Yazdanpanah,Quentin Le Hingrat,Diane Descamps,Nadhira Houhou-Fidouh,Chantal B.E.M. Reusken,Berend Jan Bosch,Christian Drosten,Marion Koopmans,Bart L. Haagmans +18 more
TL;DR: It is demonstrated that most PCR-confirmed SARS-CoV-2 infected individuals seroconverted, as revealed by sensitive and specific in-house ELISAs, and that commercial S1 IgG or IgA ELisAs were of lower specificity while sensitivity varied between the two, with IgA showing higher sensitivity.
Journal ArticleDOI
Sensitive and Specific Detection of Low-Level Antibody Responses in Mild Middle East Respiratory Syndrome Coronavirus Infections.
Nisreen M.A. Okba,V. Stalin Raj,Ivy Widjaja,Corine H. GeurtsvanKessel,Erwin de Bruin,Felicity D. Chandler,Wan Beom Park,Nam Joong Kim,Elmoubasher Farag,Mohammed Al-Hajri,Berend Jan Bosch,Myoung Don Oh,Marion Koopmans,Chantal Reusken,Bart L. Haagmans +14 more
TL;DR: Using in-house S1 ELISA and protein microarray, it is demonstrated that most PCR-confirmed MERS-CoV case-patients with mild infections seroconverted; nonetheless, some of these samples did not have detectable levels of virus-neutralizing antibodies.
Journal ArticleDOI
Antigenic cartography of SARS-CoV-2 reveals that Omicron BA.1 and BA.2 are antigenically distinct
Anna Z Mykytyn,Melanie Rissmann,Adinda Kok,Miruna E. Rosu,Debby Schipper,Tim I Breugem,Petra B. van den Doel,Felicity D. Chandler,Theo M. Bestebroer,M. M. L. de Wit,Martin E. van Royen,Richard Molenkamp,Bas B. Oude Munnink,Rory D. de Vries,Corine H. GeurtsvanKessel,Derek J. Smith,Marion Koopmans,Barry Rockx,Mart M. Lamers,Ron A. M. Fouchier,Bart L. Haagmans +20 more
TL;DR: The data show that BA.1 and BA.2 have evolved as two distinct antigenic outliers that escape vaccine-induced antibody responses as a result of different antigenic characteristics, which could be used to assess antigenic properties of future SARS-CoV-2 variants of concern that emerge and to decide on the composition of novel spike-based (booster) vaccines.
Journal ArticleDOI
Re-evaluation of routine dengue virus serology in travelers in the era of Zika virus emergence.
Maurits P.A. van Meer,Ramona Mögling,Janienne Klaasse,Felicity D. Chandler,Suzan D. Pas,Annemiek A. van der Eijk,Marion Koopmans,Chantal Reusken,Corine H. GeurtsvanKessel +8 more
TL;DR: Although the DENV NS1 antigen assay was highly specific in this cohort of laboratory confirmed ZIKV-infected travelers, high percentages of cross-reactivity of DENV IgM and IgG ELISÁs of which diagnostic laboratories should be aware are demonstrated.