R
Richard Molenkamp
Researcher at Erasmus University Rotterdam
Publications - 158
Citations - 15031
Richard Molenkamp is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Virus & Medicine. The author has an hindex of 42, co-authored 136 publications receiving 10730 citations. Previous affiliations of Richard Molenkamp include Leiden University Medical Center & University of Amsterdam.
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Journal ArticleDOI
Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR.
Victor M. Corman,Olfert Landt,Marco Kaiser,Richard Molenkamp,Adam Meijer,Daniel K.W. Chu,Tobias Bleicker,Sebastian Brünink,Julia Schneider,Marie Luisa Schmidt,Daphne G.J.C. Mulders,Bart L. Haagmans,Bas van der Veer,Sharon van den Brink,Lisa Wijsman,Gabriel Goderski,Jean Louis Romette,Joanna Ellis,Maria Zambon,Malik Peiris,Herman Goossens,Chantal B.E.M. Reusken,Marion Koopmans,Christian Drosten +23 more
TL;DR: A validated diagnostic workflow for 2019-nCoV is presented, its design relying on close genetic relatedness of 2019- nCoV with SARS coronavirus, making use of synthetic nucleic acid technology.
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Transmission of SARS-CoV-2 on mink farms between humans and mink and back to humans.
Bas B. Oude Munnink,Reina S. Sikkema,David F. Nieuwenhuijse,Robert Jan Molenaar,Emmanuelle Munger,Richard Molenkamp,Arco N. van der Spek,Paulien Tolsma,Ariene Rietveld,Miranda Brouwer,Noortje Bouwmeester-Vincken,Frank Harders,Renate Hakze-van der Honing,Marjolein C.A. Wegdam-Blans,Ruth Bouwstra,Corine H. GeurtsvanKessel,Annemiek A. van der Eijk,Francisca C. Velkers,Lidwien A.M. Smit,Arjan Stegeman,Wim H.M. van der Poel,Marion Koopmans +21 more
TL;DR: The SARS-CoV-2 virus was initially introduced by humans and has since evolved, most likely reflecting widespread circulation among mink in the beginning of the infection period, several weeks before detection.
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Phenotype and kinetics of SARS-CoV-2-specific T cells in COVID-19 patients with acute respiratory distress syndrome.
Daniela Weiskopf,Katharina S. Schmitz,Matthijs P. Raadsen,Alba Grifoni,Nisreen M.A. Okba,Henrik Endeman,Johannes P. C. van den Akker,Richard Molenkamp,Marion Koopmans,Eric C. M. van Gorp,Bart L. Haagmans,Rik L. de Swart,Alessandro Sette,Alessandro Sette,Rory D. de Vries +14 more
TL;DR: Study of COVID-19 patients who required admission to an intensive care unit and detected SARS-CoV-2-specific CD4+ and CD8+ T cells detected shed light on the potential variations in T-cell responses as a function of disease severity, an issue that is key to understanding the potential role of immunopathology in the disease.
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Duration and key determinants of infectious virus shedding in hospitalized patients with coronavirus disease-2019 (COVID-19).
Jeroen J. A. van Kampen,David A. M. C. van de Vijver,Pieter L. A. Fraaij,Bart L. Haagmans,Mart M. Lamers,Nisreen M.A. Okba,Johannes P. C. van den Akker,Henrik Endeman,Diederik Gommers,Jan J. Cornelissen,Rogier A.S. Hoek,Menno M. van der Eerden,Dennis A. Hesselink,Herold J. Metselaar,Annelies Verbon,Jurriaan E. M. de Steenwinkel,Georgina I. Aron,Eric C. M. van Gorp,Sander van Boheemen,Jolanda J.C. Voermans,Charles A. Boucher,Richard Molenkamp,Marion Koopmans,Corine H. GeurtsvanKessel,Annemiek A. van der Eijk +24 more
TL;DR: In this paper, the authors report that infectious virus shedding is detected by virus cultures in 23 of the 129 patients (17.8%) hospitalized with COVID-19, and that the median duration of shedding infectious virus is 8 days post onset of symptoms (IQR 5-11) and drops below 5% after 15.2 days after onset of symptom (95% confidence interval (CI) 13.4-17.2).
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Comparison of seven commercial RT-PCR diagnostic kits for COVID-19.
Puck B. van Kasteren,Bas van der Veer,Sharon van den Brink,Lisa Wijsman,Jørgen de Jonge,Annemarie van den Brandt,Richard Molenkamp,Chantal B.E.M. Reusken,Adam Meijer +8 more
TL;DR: All RT-PCR kits assessed in this study may be used for routine diagnostics of COVID-19 in patients by experienced molecular diagnostic laboratories and none of the assays showed cross-reactivity with other respiratory (corona)viruses, except as expected for the SARS-CoV-1 E-gene.