V
V. Stalin Raj
Researcher at Erasmus University Rotterdam
Publications - 59
Citations - 8450
V. Stalin Raj is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Middle East respiratory syndrome coronavirus & Coronavirus. The author has an hindex of 36, co-authored 59 publications receiving 7301 citations. Previous affiliations of V. Stalin Raj include Indian Institute of Science Education and Research, Thiruvananthapuram & University of Liège.
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Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC
V. Stalin Raj,Huihui Mou,Saskia L. Smits,Dick H. W. Dekkers,Marcel A. Müller,Ronald Dijkman,Doreen Muth,Jeroen Demmers,Ali Moh Zaki,Ron A. M. Fouchier,Volker Thiel,Volker Thiel,Christian Drosten,Peter J. M. Rottier,Albert D. M. E. Osterhaus,Berend Jan Bosch,Bart L. Haagmans +16 more
TL;DR: Dipeptidyl peptidase 4 (DPP4; also known as CD26) is identified as a functional receptor for hCoV-EMC and will contribute critically to the understanding of the pathogenesis and epidemiology of this emerging human coronavirus, and may facilitate the development of intervention strategies.
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Genomic Characterization of a Newly Discovered Coronavirus Associated with Acute Respiratory Distress Syndrome in Humans
Sander van Boheemen,Miranda de Graaf,Chris Lauber,Theo M. Bestebroer,V. Stalin Raj,Ali Moh Zaki,Albert D. M. E. Osterhaus,Bart L. Haagmans,Alexander E. Gorbalenya,Alexander E. Gorbalenya,Eric J. Snijder,Ron A. M. Fouchier +11 more
TL;DR: It is proposed that a novel human coronavirus isolated from a man with acute pneumonia and renal failure in June 2012 prototypes a novel species in the genus Betacoronavirus, which is closely related to bat coronaviruses that are distant from SARS-CoV.
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Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study
Chantal B.E.M. Reusken,Bart L. Haagmans,Marcel A. Müller,Carlos Gutierrez,Gert Jan Godeke,Benjamin Meyer,Doreen Muth,V. Stalin Raj,Laura Smits De Vries,Victor M. Corman,Jan Felix Drexler,Saskia L. Smits,Yasmin El Tahir,Rita de Sousa,Janko van Beek,Norbert Nowotny,Norbert Nowotny,Kees van Maanen,Ezequiel Hidalgo-Hermoso,Berend Jan Bosch,Peter J. M. Rottier,Albert D. M. E. Osterhaus,Christian Gortázar-Schmidt,Christian Drosten,Marion Koopmans +24 more
TL;DR: Both titres and seroprevalences in sera from different locations in Oman suggest widespread infection of camel populations, and possible animal reservoirs of MERS-CoV are investigated by assessing specific serum antibodies in livestock.
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Middle East respiratory syndrome coronavirus in dromedary camels: An outbreak investigation
Bart L. Haagmans,Said H.S. Al Dhahiry,Chantal B.E.M. Reusken,V. Stalin Raj,Monica Galiano,Richard M. Myers,Gert Jan Godeke,Marcel Jonges,Elmoubasher Farag,Ayman Diab,Hazem Ghobashy,Farhoud Alhajri,Mohamed H. Al-Thani,Salih A. Al-Marri,Hamad Eid Al Romaihi,Abdullatif Al Khal,Alison Bermingham,Albert D. M. E. Osterhaus,Mohd M. AlHajri,Marion Koopmans +19 more
TL;DR: This study provides virological confirmation of MERS-CoV in camels and suggests a recent outbreak affecting both human beings and camels.
Journal ArticleDOI
MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-α treatment
Adriaan H. de Wilde,V. Stalin Raj,Diede Oudshoorn,Theo M. Bestebroer,Stefan van Nieuwkoop,Ronald W. A. L. Limpens,Clara C. Posthuma,Yvonne van der Meer,Montserrat Bárcena,Bart L. Haagmans,Eric J. Snijder,Bernadette G. van den Hoogen +11 more
TL;DR: MERS- coV infection did not prevent the IFN-induced nuclear translocation of phosphorylated STAT1, in contrast to infection with SARS-CoV where this block inhibits the expression of antiviral genes, and this findings highlight relevant differences between these distantly related zoonotic CoVs in terms of their interaction with and evasion of the cellular innate immune response.