M
Mart M. Lamers
Researcher at Erasmus University Rotterdam
Publications - 70
Citations - 7796
Mart M. Lamers is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 25, co-authored 47 publications receiving 4548 citations. Previous affiliations of Mart M. Lamers include University of Amsterdam & University of Hong Kong.
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Journal ArticleDOI
Severe Acute Respiratory Syndrome Coronavirus 2-Specific Antibody Responses in Coronavirus Disease Patients
Nisreen M.A. Okba,Marcel A. Müller,Wentao Li,Chunyan Wang,Corine H. GeurtsvanKessel,Victor M. Corman,Mart M. Lamers,Reina S. Sikkema,Erwin de Bruin,Felicity D. Chandler,Yazdan Yazdanpanah,Quentin Le Hingrat,Diane Descamps,Nadhira Houhou-Fidouh,Chantal B.E.M. Reusken,Berend Jan Bosch,Christian Drosten,Marion Koopmans,Bart L. Haagmans +18 more
TL;DR: It is demonstrated that most PCR-confirmed SARS-CoV-2–infected persons seroconverted by 2 weeks after disease onset, and validated and tested various antigens in different in-house and commercial ELISAs, finding that commercial S1 IgG or IgA ELISA were of lower specificity, and sensitivity varied between the 2 assays; the IgAELISA showed higher sensitivity.
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SARS-CoV-2 productively infects human gut enterocytes.
Mart M. Lamers,Joep Beumer,Jelte van der Vaart,Kèvin Knoops,Jens Puschhof,Tim I Breugem,Raimond B. G. Ravelli,J. Paul van Schayck,Anna Z Mykytyn,Hans Duimel,Elly van Donselaar,Samra Riesebosch,Helma J.H. Kuijpers,Debby Schipper,Willine J. van de Wetering,Miranda de Graaf,Marion Koopmans,Edwin Cuppen,Peter J. Peters,Bart L. Haagmans,Hans Clevers +20 more
TL;DR: It is demonstrated that intestinal organoids can serve as a model to understand SARS-CoV-2 biology and infectivity in the gut, and hSIOs serve as an experimental model for coronavirus infection and biology.
Journal ArticleDOI
Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model.
Barry Rockx,Thijs Kuiken,Sander Herfst,Theo M. Bestebroer,Mart M. Lamers,Bas B. Oude Munnink,Dennis de Meulder,Geert van Amerongen,Judith M. A. van den Brand,Nisreen M.A. Okba,Debby Schipper,Peter van Run,Lonneke Leijten,Reina S. Sikkema,Ernst J. Verschoor,Babs E. Verstrepen,Willy M. J. M. Bogers,Jan A.M. Langermans,Jan A.M. Langermans,Christian Drosten,Martje Fentener van Vlissingen,Ron A. M. Fouchier,Rik L. de Swart,Marion Koopmans,Bart L. Haagmans +24 more
TL;DR: Comparisons of three human coronaviruses in cynomolgus macaques show that SARS-CoV-2 causes COVID-19–like disease in macaques and provides a new model to test preventive and therapeutic strategies.
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Duration and key determinants of infectious virus shedding in hospitalized patients with coronavirus disease-2019 (COVID-19).
Jeroen J. A. van Kampen,David A. M. C. van de Vijver,Pieter L. A. Fraaij,Bart L. Haagmans,Mart M. Lamers,Nisreen M.A. Okba,Johannes P. C. van den Akker,Henrik Endeman,Diederik Gommers,Jan J. Cornelissen,Rogier A.S. Hoek,Menno M. van der Eerden,Dennis A. Hesselink,Herold J. Metselaar,Annelies Verbon,Jurriaan E. M. de Steenwinkel,Georgina I. Aron,Eric C. M. van Gorp,Sander van Boheemen,Jolanda J.C. Voermans,Charles A. Boucher,Richard Molenkamp,Marion Koopmans,Corine H. GeurtsvanKessel,Annemiek A. van der Eijk +24 more
TL;DR: In this paper, the authors report that infectious virus shedding is detected by virus cultures in 23 of the 129 patients (17.8%) hospitalized with COVID-19, and that the median duration of shedding infectious virus is 8 days post onset of symptoms (IQR 5-11) and drops below 5% after 15.2 days after onset of symptom (95% confidence interval (CI) 13.4-17.2).
Journal ArticleDOI
SARS-CoV-2 is transmitted via contact and via the air between ferrets.
Mathilde Richard,Adinda Kok,Dennis de Meulder,Theo M. Bestebroer,Mart M. Lamers,Nisreen M.A. Okba,Martje Fentener van Vlissingen,Barry Rockx,Bart L. Haagmans,Marion Koopmans,Ron A. M. Fouchier,Sander Herfst +11 more
TL;DR: Experimental evidence of robust transmission of SARS-CoV-2 via the air is provided, supporting the implementation of community-level social distancing measures currently applied in many countries in the world and informing decisions on infection control measures in healthcare settings.