F
Femke H. Bouwman
Researcher at VU University Amsterdam
Publications - 162
Citations - 6542
Femke H. Bouwman is an academic researcher from VU University Amsterdam. The author has contributed to research in topics: Dementia & Medicine. The author has an hindex of 40, co-authored 134 publications receiving 5032 citations. Previous affiliations of Femke H. Bouwman include Johns Hopkins University & VU University Medical Center.
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Journal ArticleDOI
Amyloid-β(1–42), Total Tau, and Phosphorylated Tau as Cerebrospinal Fluid Biomarkers for the Diagnosis of Alzheimer Disease
Cees Mulder,Nicolaas A. Verwey,Wiesje M. van der Flier,Femke H. Bouwman,Astrid Kok,Evert J. van Elk,Philip Scheltens,Marinus A. Blankenstein +7 more
TL;DR: CSF biomarkers Abeta42 and Tau can be used as a diagnostic aid in AD and pTau did not have additional value over these 2 markers.
Journal ArticleDOI
Optimizing patient care and research: the Amsterdam Dementia Cohort
Wiesje M. van der Flier,Yolande A.L. Pijnenburg,Niels D. Prins,Afina W. Lemstra,Femke H. Bouwman,Charlotte E. Teunissen,Bart N.M. van Berckel,Cornelis J. Stam,Frederik Barkhof,Pieter Jelle Visser,Evan van Egmond,Philip Scheltens +11 more
TL;DR: The Amsterdam Dementia Cohort forms the basis of much of the research, which focuses on four major research lines: 1) variability in manifestation, 2) early diagnosis, 3) vascular factors, and 4) interventions.
Journal ArticleDOI
Intrathecal chemokine synthesis in mild cognitive impairment and Alzheimer disease.
Daniela Galimberti,N. S. M. Schoonenboom,Philip Scheltens,Chiara Fenoglio,Femke H. Bouwman,Eliana Venturelli,Ilaria Guidi,Marinus A. Blankenstein,Nereo Bresolin,Elio Scarpini +9 more
TL;DR: Interferon-gamma-inducible protein 10 is specifically increased in MCI and seems to decrease with the progression of AD, whereas MCP-1 and IL-8 are up-regulated also in late stages of the disease, suggesting a role in phases in which neurodegeneration is prevalent.
Journal ArticleDOI
The cerebrospinal fluid “Alzheimer profile”: Easily said, but what does it mean?
Flora H. Duits,Charlotte E. Teunissen,Femke H. Bouwman,Pieter Jelle Visser,Pieter Jelle Visser,Niklas Mattsson,Niklas Mattsson,Henrik Zetterberg,Henrik Zetterberg,Kaj Blennow,Oskar Hansson,Lennart Minthon,Niels Andreasen,Jan Marcusson,Anders Wallin,Marcel G. M. Olde Rikkert,Magda Tsolaki,Lucilla Parnetti,Sanna-Kaisa Herukka,Harald Hampel,Mony J. de Leon,Johannes Schröder,Dag Aarsland,Marinus A. Blankenstein,Philip Scheltens,Wiesje M. van der Flier +25 more
TL;DR: In this paper, the most useful definition of the "cerebrospinal fluid Alzheimer profile," based on amyloid-s 1-42 (Aβ 42 ), total tau, and phosphorylated tau (p-tau), for diagnosis and prognosis of Alzheimer's disease (AD) was identified.
Journal ArticleDOI
CSF biomarkers and medial temporal lobe atrophy predict dementia in mild cognitive impairment.
Femke H. Bouwman,S.N.M. Schoonenboom,W.M. van der Flier,E. J. van Elk,Astrid Kok,Frederik Barkhof,Marinus A. Blankenstein,Ph. Scheltens +7 more
TL;DR: Findings suggest an added value of CSF to MRI in the diagnostic work up of patients presenting at a memory clinic and a fourfold higher risk was found for patients with both abnormal CSF biomarkers and MTA compared to patients with either test abnormal.