F
Feng Yun Yue
Researcher at University of Toronto
Publications - 35
Citations - 2469
Feng Yun Yue is an academic researcher from University of Toronto. The author has contributed to research in topics: Cytotoxic T cell & T cell. The author has an hindex of 20, co-authored 31 publications receiving 2038 citations.
Papers
More filters
Journal ArticleDOI
Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection
R. Brad Jones,Lishomwa C. Ndhlovu,Jason D. Barbour,Prameet M. Sheth,Aashish R. Jha,Brian Long,Jessica Wong,Malathy Satkunarajah,Marc Schweneker,Joan M. Chapman,Gabor Gyenes,Bahareh Vali,Martin D. Hyrcza,Feng Yun Yue,Colin Kovacs,Aref Sassi,Mona R. Loutfy,Roberta Halpenny,Desmond Persad,Gerald Spotts,Frederick Hecht,Tae-Wook Chun,Joseph M. McCune,Rupert Kaul,James M. Rini,Douglas F. Nixon,Mario A. Ostrowski +26 more
TL;DR: Blocking the Tim-3 signaling pathway restored proliferation and enhanced cytokine production in HIV-1–specific T cells and represents a novel target for the therapeutic reversal of HIV–1–associated T cell dysfunction.
Journal ArticleDOI
Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in COVID-19 patients.
Baweleta Isho,Kento T. Abe,Kento T. Abe,Michelle Zuo,Alainna J Jamal,Alainna J Jamal,Bhavisha Rathod,Jenny Wang,Zhijie Li,Gary Chao,Olga L. Rojas,Yeo Myong Bang,Annie Pu,Natasha Christie-Holmes,Christian Gervais,Derek F. Ceccarelli,Payman Samavarchi-Tehrani,Furkan Guvenc,Patrick Budylowski,Angel Li,Aimee Paterson,Feng Yun Yue,Lina María Marín,Lauren Caldwell,Jeffrey L. Wrana,Jeffrey L. Wrana,Karen Colwill,Frank Sicheri,Frank Sicheri,Samira Mubareka,Scott D. Gray-Owen,Steven J. Drews,Walter L. Siqueira,Miriam Barrios-Rodiles,Mario A. Ostrowski,Mario A. Ostrowski,James M. Rini,Yves Durocher,Allison McGeer,Allison McGeer,Allison McGeer,Jennifer L. Gommerman,Anne-Claude Gingras,Anne-Claude Gingras +43 more
TL;DR: It is confirmed that serum and saliva IgG antibodies to SARS-CoV-2 are maintained in the majority of COVID-19 patients for at least 3 months PSO, and IgG responses in saliva may serve as a surrogate measure of systemic immunity to Sars-Cov-2 based on their correlation with serum IgG responds.
Journal ArticleDOI
The role of the p38 mitogen-activated protein kinase, extracellular signal-regulated kinase, and phosphoinositide-3-OH kinase signal transduction pathways in CD40 ligand-induced dendritic cell activation and expansion of virus-specific CD8+ T cell memory responses.
TL;DR: The p38 MAPK pathway within CD40L-conditioned DCs is the most important pathway to maximally elicit T cell immune responses and should be exploited in vivo to either completely suppress or enhance CD8+ Tcell immune responses.
Journal ArticleDOI
HIV-Specific IL-21 Producing CD4+ T Cells Are Induced in Acute and Chronic Progressive HIV Infection and Are Associated with Relative Viral Control
Feng Yun Yue,Calvin Lo,Ali Sakhdari,Erika Yue Lee,Colin Kovacs,Erika Benko,Jun Liu,Haihan Song,R. Brad Jones,Prameet M. Sheth,Duncan Chege,Rupert Kaul,Mario A. Ostrowski +12 more
TL;DR: IL-21–producing CD4+ T cells are induced in viremic HIV infection and likely contribute to viral control by affecting CD8+ T cell maintenance.
Journal ArticleDOI
IL-10-producing B cells are induced early in HIV-1 infection and suppress HIV-1-specific T cell responses.
Jun Liu,Wei Zhan,Connie J. Kim,Kiera L. Clayton,Hanqi Zhao,Erika Lee,Jin Chao Cao,Blake E. Ziegler,Alexander Gregor,Feng Yun Yue,Sanja Huibner,Sonya A. MacParland,Jordan A. Schwartz,Hai Han Song,Erika Benko,Gabor Gyenes,Colin Kovacs,Rupert Kaul,Mario A. Ostrowski +18 more
TL;DR: Findings show that IL-10-producing B cells are induced early in HIV-1 infection, can be HIV- 1 specific, and are able to inhibit effective anti-HIV-1 T cell responses.