F
Fernanda Vargas E Silva Castanheira
Researcher at University of Calgary
Publications - 4
Citations - 529
Fernanda Vargas E Silva Castanheira is an academic researcher from University of Calgary. The author has contributed to research in topics: Neutrophil extracellular traps & Innate immune system. The author has an hindex of 3, co-authored 4 publications receiving 205 citations.
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Journal ArticleDOI
Neutrophils and NETs in modulating acute and chronic inflammation
TL;DR: The mechanisms of NET formation are discussed, as well as the apparent paradoxical role of neutrophils and NETs in host defense, chronic inflammation, and tissue disrepair.
Journal ArticleDOI
Patrolling Alveolar Macrophages Conceal Bacteria from the Immune System to Maintain Homeostasis.
Arpan Sharma Neupane,Michelle Elizabeth Willson,Andrew Chojnacki,Fernanda Vargas E Silva Castanheira,Christopher Morehouse,Agostina Carestia,Ashley E. Keller,Moritz Peiseler,Antonio DiGiandomenico,Margaret M. Kelly,Matthias Amrein,Craig N. Jenne,Ajitha Thanabalasuriar,Paul Kubes +13 more
TL;DR: In a disease context, influenza A virus infection impaired AM crawling via the type II interferon signaling pathway, and this greatly increased secondary bacterial co-infection, leading to inappropriate inflammation and injury.
Journal ArticleDOI
Macrophage galactose lectin is critical for Kupffer cells to clear aged platelets.
Carsten Deppermann,Carsten Deppermann,Rachel M. Kratofil,Moritz Peiseler,Bruna Araújo David,Joel Zindel,Fernanda Vargas E Silva Castanheira,Fardau van der Wal,Agostina Carestia,Craig N. Jenne,Jamey D. Marth,Paul Kubes +11 more
TL;DR: Using intravital microscopy, Deppermann et al. investigate how aged platelets are removed from circulation through collaboration of macrophage galactose lectin and Ashwell-Morell receptor to observe rapid accumulation of desialylated platelets on Kupffer cells.
Posted ContentDOI
A functionally distinct neutrophil landscape in severe COVID-19 reveals opportunities for adjunctive therapies
Rachita Panda,Fernanda Vargas E Silva Castanheira,Jared Schlechte,Bas Gj Surewaard,Hanjoo Brian Shim,Amanda Z. Zucoloto,Zdenka Slavikova,Bryan G. Yipp,Paul Kubes,Braedon McDonald +9 more
TL;DR: In this article, a combination of high-dimensional single cell analysis and ex vivo functional assays of neutrophils from patients with acute respiratory distress syndrome (ARDS) compared to non-COVID ARDS (caused by bacterial pneumonia) was performed.