M
Margaret M. Kelly
Researcher at University of Calgary
Publications - 82
Citations - 5432
Margaret M. Kelly is an academic researcher from University of Calgary. The author has contributed to research in topics: Sputum & Fibrosis. The author has an hindex of 28, co-authored 80 publications receiving 4594 citations. Previous affiliations of Margaret M. Kelly include Alberta Children's Hospital & St. Joseph Hospital.
Papers
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Journal ArticleDOI
Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood
Stephen Clark,Adrienne C. Ma,Samantha A. Tavener,Braedon McDonald,Zahra Goodarzi,Margaret M. Kelly,Kamala D. Patel,Subhadeep Chakrabarti,Erin F. McAvoy,Gary D. Sinclair,Elizabeth Keys,Emma Allen-Vercoe,Rebekah DeVinney,Christopher J. Doig,Francis H. Y. Green,Paul Kubes +15 more
TL;DR: It is proposed that platelet TLR4 is a threshold switch for this new bacterial trapping mechanism in severe sepsis, where NETs have the greatest capacity for bacterial trapping.
Journal ArticleDOI
Transient Overexpression of TGF-β1 Induces Epithelial Mesenchymal Transition in the Rodent Peritoneum
Peter J. Margetts,Philippe Bonniaud,Limin Liu,Catherine M. Hoff,Clifford J. Holmes,Judith A. West-Mays,Margaret M. Kelly +6 more
TL;DR: Findings suggest that EMT occurs in vivo after TGF-beta1 overexpression in the peritoneum and further supports the central role of T GF- beta1 in peritoneal fibrosis and provides an important model to study the sequence of events involved in TGF -beta1-induced EMT.
Journal ArticleDOI
Methods of sputum processing for cell counts, immunocytochemistry and in situ hybridisation
A. Efthimiadis,Antonio Spanevello,Qutayba Hamid,Margaret M. Kelly,M. Linden,Renaud Louis,Marcia Margaret Menezes Pizzichini,Emilio Pizzichini,C. Ronchi,F. J. van Overveld,Ratko Djukanovic +10 more
TL;DR: Two methods for processing the expectorate have evolved and there is conflicting data as to whether or not differential cell counts (DCCs) differ between the two methods.
Journal ArticleDOI
Modulating leukocyte recruitment in inflammation
TL;DR: The leukocyte recruitment cascade is summarized, highlighting the molecular mechanisms that underlie each of the major steps and major emphasis is placed on the selectins and integrins and their role in rolling and adhesion.
Journal ArticleDOI
A GABAergic system in airway epithelium is essential for mucus overproduction in asthma
Xiang Yy,Wang S,Mingyao Liu,Jeremy A. Hirota,Li J,Li J,Ju W,Fan Y,Margaret M. Kelly,Ye B,Beverley A. Orser,Paul M. O'Byrne,Inman,Xi Yang,Wei-Yang Lu,Wei-Yang Lu +15 more
TL;DR: It is shown that an excitatory, rather than inhibitory, GABAergic system exists in airway epithelial cells and has an essential role in asthma.