F
Fernande René-Corail
Researcher at Paris Descartes University
Publications - 26
Citations - 3393
Fernande René-Corail is an academic researcher from Paris Descartes University. The author has contributed to research in topics: PRKAR1A & Carney complex. The author has an hindex of 22, co-authored 26 publications receiving 2991 citations. Previous affiliations of Fernande René-Corail include University of Paris & Centre national de la recherche scientifique.
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Journal ArticleDOI
Integrated genomic characterization of adrenocortical carcinoma
Guillaume Assié,Eric Letouzé,Martin Fassnacht,Anne Jouinot,W. Luscap,Olivia Barreau,H. Omeiri,S. Rodriguez,Karine Perlemoine,Fernande René-Corail,Nabila Elarouci,Silviu Sbiera,Matthias Kroiss,Bruno Allolio,Jens Waldmann,Marcus Quinkler,Massimo Mannelli,Franco Mantero,Thomas G. Papathomas,Ronald R. de Krijger,Antoine Tabarin,Véronique Kerlan,Eric Baudin,Frédérique Tissier,Bertrand Dousset,Lionel Groussin,Laurence Amar,Eric Clauser,Xavier Bertagna,Bruno Ragazzon,Felix Beuschlein,Rossella Libé,Aurélien de Reyniès,Jérôme Bertherat +33 more
TL;DR: Aggressive and indolent ACCs correspond to two distinct molecular entities driven by different oncogenic alterations, which are validated in an independent cohort of 77 ACCs.
Journal ArticleDOI
Mutations of β-Catenin in Adrenocortical Tumors: Activation of the Wnt Signaling Pathway Is a Frequent Event in both Benign and Malignant Adrenocortical Tumors
Frédérique Tissier,Catherine Cavard,Lionel Groussin,Karine Perlemoine,Gwladys Fumey,Anne-Marie Hagnere,Fernande René-Corail,E. Jullian,Christine Gicquel,Xavier Bertagna,Marie-Cécile Vacher-Lavenu,Christine Perret,Jérôme Bertherat +12 more
TL;DR: Functional studies showed that the activating Ser45 beta-catenin mutation found in the adrenocortical cancer H295R cell line leads to constitutive activation of T-cell factor-dependent transcription, the first molecular defect to be reported with the same prevalence in both benign and malignant adrenOCortical tumors.
Journal ArticleDOI
Mutations in regulatory subunit type 1A of cyclic adenosine 5'-monophosphate-dependent protein kinase (PRKAR1A): phenotype analysis in 353 patients and 80 different genotypes.
Jérôme Bertherat,Jérôme Bertherat,Anelia Horvath,Lionel Groussin,Lionel Groussin,Sophie Grabar,Sosipatros Boikos,Laure Cazabat,R. Libe,Fernande René-Corail,Fernande René-Corail,Sotirios Stergiopoulos,Isabelle Bourdeau,Thalia Bei,Eric Clauser,Alain Calender,Lawrence S. Kirschner,Xavier Bertagna,Xavier Bertagna,J. Aidan Carney,Constantine A. Stratakis +20 more
TL;DR: Patients with a PRKAR1A mutation were more likely to have pigmented skin lesions, myxomas, and thyroid and gonadal tumors; they also presented earlier with these tumors; and nonexpressed PRKar1A mutations were associated with less severe disease.
Journal ArticleDOI
Gene Expression Profiling Reveals a New Classification of Adrenocortical Tumors and Identifies Molecular Predictors of Malignancy and Survival
Aurélien de Reyniès,Guillaume Assié,David S. Rickman,Frédérique Tissier,Lionel Groussin,Fernande René-Corail,Bertrand Dousset,Xavier Bertagna,Eric Clauser,Jérôme Bertherat +9 more
TL;DR: In this article, the authors identify molecular predictors of malignancy and of survival for the purpose of diagnosis and prognosis assessment of malignant tumors in Adrenocortical tumors.
Journal ArticleDOI
ARMC5 Mutations in Macronodular Adrenal Hyperplasia with Cushing's Syndrome
Guillaume Assié,Rossella Libé,Stéphanie Espiard,Marthe Rizk-Rabin,Anne Guimier,W. Luscap,Olivia Barreau,Lucile Lefèvre,Mathilde Sibony,Laurence Guignat,Stéphanie Rodriguez,Karine Perlemoine,Fernande René-Corail,Franck Letourneur,Bilal Trabulsi,Alix Poussier,Nathalie Chabbert-Buffet,Françoise Borson-Chazot,Lionel Groussin,Xavier Bertagna,Constantine A. Stratakis,Bruno Ragazzon,Jérôme Bertherat +22 more
TL;DR: In this paper, the effects of armadillo repeat containing 5 (ARMC5) inactivation and overexpression were tested in cell-culture models and the most frequent somatic chromosome alteration was loss of heterozygosity at 16p (in 8 of 33 patients for whom data were available [24%]).