R
Ronald R. de Krijger
Researcher at Erasmus University Rotterdam
Publications - 180
Citations - 9058
Ronald R. de Krijger is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Paraganglioma & SDHD. The author has an hindex of 46, co-authored 152 publications receiving 7995 citations. Previous affiliations of Ronald R. de Krijger include Radboud University Nijmegen & University of Cambridge.
Papers
More filters
Journal ArticleDOI
Defects in succinate dehydrogenase in gastrointestinal stromal tumors lacking KIT and PDGFRA mutations
Katherine A. Janeway,Su Young Kim,Maya Lodish,Vânia Nosé,Pierre Rustin,José Gaal,Patricia L. M. Dahia,Bernadette Liegl,Evan R. Ball,Margarita Raygada,Angela H. Lai,Lorna Kelly,Jason L. Hornick,wild-type Gist Clinic,Maureen J. O'Sullivan,Ronald R. de Krijger,Winand N.M. Dinjens,George D. Demetri,Cristina R. Antonescu,Jonathan A. Fletcher,Lee J. Helman,Constantine A. Stratakis +21 more
TL;DR: WT GISTs, particularly those in younger patients, have defects in SDH mitochondrial complex II, and in a subset of these patients, GIST seems to arise from germline-inactivating SDH mutations.
Journal ArticleDOI
Integrated genomic characterization of adrenocortical carcinoma
Guillaume Assié,Eric Letouzé,Martin Fassnacht,Anne Jouinot,W. Luscap,Olivia Barreau,H. Omeiri,S. Rodriguez,Karine Perlemoine,Fernande René-Corail,Nabila Elarouci,Silviu Sbiera,Matthias Kroiss,Bruno Allolio,Jens Waldmann,Marcus Quinkler,Massimo Mannelli,Franco Mantero,Thomas G. Papathomas,Ronald R. de Krijger,Antoine Tabarin,Véronique Kerlan,Eric Baudin,Frédérique Tissier,Bertrand Dousset,Lionel Groussin,Laurence Amar,Eric Clauser,Xavier Bertagna,Bruno Ragazzon,Felix Beuschlein,Rossella Libé,Aurélien de Reyniès,Jérôme Bertherat +33 more
TL;DR: Aggressive and indolent ACCs correspond to two distinct molecular entities driven by different oncogenic alterations, which are validated in an independent cohort of 77 ACCs.
Journal ArticleDOI
An immunohistochemical procedure to detect patients with paraganglioma and phaeochromocytoma with germline SDHB, SDHC, or SDHD gene mutations: a retrospective and prospective analysis.
Francien H van Nederveen,José Gaal,Judith Favier,Esther Korpershoek,Rogier A. Oldenburg,Elly M C A de Bruyn,Hein F.B.M. Sleddens,Pieter Derkx,Julie Rivière,Hilde Dannenberg,Bart-Jeroen Petri,Paul Komminoth,Karel Pacak,Wim C. J. Hop,Patrick J. Pollard,Massimo Mannelli,Jean-Pierre Bayley,Aurel Perren,Stephan Niemann,Albert A.J. Verhofstad,Adriaan P. de Bruïne,Eamonn R. Maher,Frédérique Tissier,Tchao Meatchi,Cécile Badoual,Jérôme Bertherat,Laurence Amar,Despoina Alataki,Eric Van Marck,Francesco Ferraù,Jerney François,Wouter W. de Herder,Mark-Paul F M Vrancken Peeters,Anne van Linge,Jacques W.M. Lenders,Jacques W.M. Lenders,Anne-Paule Gimenez-Roqueplo,Ronald R. de Krijger,Winand N.M. Dinjens +38 more
TL;DR: Phaeochromocytoma-paraganglioma syndrome can be diagnosed reliably by an immunohistochemical procedure and SDHB immunohistsochemistry could improve the diagnosis, according to a large retrospective and prospective tumour series.
Journal ArticleDOI
Malignant pheochromocytoma: Current status and initiatives for future progress
Graeme Eisenhofer,Stefan R. Bornstein,Frederieke M. Brouwers,Nai-Kong V. Cheung,Patricia L. M. Dahia,Ronald R. de Krijger,Thomas J. Giordano,Lloyd A. Greene,David S. Goldstein,Hendrik Lehnert,William M. Manger,John M. Maris,Hartmut P. H. Neumann,Karel Pacak,Barry L. Shulkin,David I. Smith,Arthur S. Tischler,William F. Young +17 more
TL;DR: The well-characterized hereditary basis and the unique functional nature of these neuroendocrine tumors provide a useful framework that offers advantages for establishing the pathways of tumorigenesis and malignancy.
Journal ArticleDOI
SDHA Immunohistochemistry Detects Germline SDHA Gene Mutations in Apparently Sporadic Paragangliomas and Pheochromocytomas
Esther Korpershoek,Judith Favier,Judith Favier,José Gaal,Nelly Burnichon,Nelly Burnichon,Bram van Gessel,Lindsey Oudijk,Cécile Badoual,Noémie Gadessaud,Noémie Gadessaud,Annabelle Venisse,Jean-Pierre Bayley,Marieke F. van Dooren,Wouter W. de Herder,Frédérique Tissier,Pierre-François Plouin,Francien H van Nederveen,Winand N.M. Dinjens,Anne-Paule Gimenez-Roqueplo,Anne-Paule Gimenez-Roqueplo,Ronald R. de Krijger +21 more
TL;DR: It is demonstrated that SDHA immunohistochemistry on paraffin-embedded tumors can reveal the presence ofSDHA germline mutations and allowed the identification of SDHA-related tumors in at least 3% of patients affected by apparently sporadic (para)sympathetic paragangliomas and pheochromocytomas.