Ferran Jardi

TL;DR: Key musculoskeletal molecular pathways involved in mechanoregulation and their effect on the bone-muscle unit as a whole are reviewed, as well as preclinical and emerging clinical evidence regarding the effects of sarcopenia therapies on osteoporosis and vice versa are reviewed.

TL;DR: Despite markedly raised total sex steroid concentrations, free testosterone was unaffected while sex steroid bioactivity on male and female reproductive organs was attenuated, and this occurred via a ligand-dependent, genotype-independent mechanism according to in vitro seminal vesicle organ cultures.

TL;DR: It is concluded that sex steroid deficiency in combination with HFD exacerbates adiposity, insulin resistance, and β-cell failure in 2 preclinical male mouse models and may have implications for the prevention of metabolic alterations in hypogonadal men.

TL;DR: It is indicated that GTx-024 does not selectively modulate AR in the satellite cell lineage and that cells outside this lineage remain androgen responsive in satARKO muscle, and cells inside this lineage also contribute to the anabolic effects of androgens.

TL;DR: Findings reveal that the free fraction of T, both via AR and indirectly through aromatization into estrogens, stimulates physical activity behavior in male mice by acting on central DA pathways.