F
Fiona Crawford
Researcher at Roskamp Institute
Publications - 218
Citations - 21532
Fiona Crawford is an academic researcher from Roskamp Institute. The author has contributed to research in topics: Apolipoprotein E & Traumatic brain injury. The author has an hindex of 54, co-authored 204 publications receiving 20103 citations. Previous affiliations of Fiona Crawford include University of Antwerp & Archer.
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Journal ArticleDOI
Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease.
Alison Goate,Marie-Christine Chartier-Harlin,Michael Mullan,Jeremy P Brown,Fiona Crawford,Liana Fidani,L. Giuffra,Andrew Haynes,N.G. Irving,Louise James,R. Mant,Phillippa Newton,Karen Rooke,P Roques,Christopher Talbot,Margaret A. Pericak-Vance,Alien D. Roses,Robert Williamson,Martin N. Rossor,Michael John Owen,John Hardy +20 more
TL;DR: A locus segregating with familial Alzheimer's disease (AD) has been mapped to chromosome 21, close to the amyloid precursor protein (APP) gene as discussed by the authors, which suggests that some cases of AD could be caused by mutations in the APP gene.
Segregation of a missense mutation in the amyloid precursor protein gene with familial alzheimers-disease
A. Goate,M-C. Chartier-Harlin,Michael Mullan,J Brown,Fiona Crawford,Liana Fidani,L Giuffra,A. Haynes,N Irving,L James,R Mant,P. J. Newton,K Rooke,P Roques,C. Conover Talbot,Pericak-Vance Margareta A,A. Roses,Robert Williamson,Martin N. Rossor,M. J. Owen,John Hardy +20 more
TL;DR: It is demonstrated that in this kindred, which shows linkage to chromosome 21 markers, there is a point mutation in the APP gene that causes an amino-acid substitution close to the carboxy terminus of the β-amyloid peptide.
Journal ArticleDOI
A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid.
Michael Mullan,Fiona Crawford,Karin Axelman,Henry Houlden,Lena Lilius,Bengt Winblad,Lars Lannfelt +6 more
TL;DR: A double mutation at codons 670 and 671 (APP 770 transcript) in exon 16 which co–segregates with the disease in two large (probably related) early–onset Alzheimer's disease families from Sweden is identified.
Journal ArticleDOI
Early-onset Alzheimer's disease caused by mutations at codon 717 of the β-amyloid precursor protein gene
Marie-Christine Chartier-Harlin,Fiona Crawford,Henry Houlden,Andrew Warren,David Hughes,Liana Fidani,Alison Goate,Martin N. Rossor,P Roques,John Hardy,Michael Mullan +10 more
TL;DR: The occurrence of a second allelic variant at codon 717 linked to the Alzheimer's phenotype supports the hypothesis that they are pathogenic mutations.
Journal ArticleDOI
Microglial Activation Resulting from CD40-CD40L Interaction After β-Amyloid Stimulation
Jun Tan,Terrence Town,Daniel Paris,Takashi Mori,Zhiming Suo,Fiona Crawford,Mark P. Mattson,Richard A. Flavell,Michael Mullan +8 more
TL;DR: CD40 expression was increased and abnormal tau phosphorylation was reduced in Tg APPsw animals deficient for CD40L, suggesting that the CD40-CD40L interaction is an early event in AD pathogenesis.