J
J Brown
Researcher at University of Bristol
Publications - 10
Citations - 4708
J Brown is an academic researcher from University of Bristol. The author has contributed to research in topics: Hippocampal formation & Hippocampus. The author has an hindex of 9, co-authored 10 publications receiving 4529 citations.
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Segregation of a missense mutation in the amyloid precursor protein gene with familial alzheimers-disease
A. Goate,M-C. Chartier-Harlin,Michael Mullan,J Brown,Fiona Crawford,Liana Fidani,L Giuffra,A. Haynes,N Irving,L James,R Mant,P. J. Newton,K Rooke,P Roques,C. Conover Talbot,Pericak-Vance Margareta A,A. Roses,Robert Williamson,Martin N. Rossor,M. J. Owen,John Hardy +20 more
TL;DR: It is demonstrated that in this kindred, which shows linkage to chromosome 21 markers, there is a point mutation in the APP gene that causes an amino-acid substitution close to the carboxy terminus of the β-amyloid peptide.
Journal Article
A locus for familial non specific dementia maps to chromosome-3
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Altered intrinsic pyramidal neuron properties and pathway- specific synaptic dysfunction underlie aberrant hippocampal network function in a mouse model of tauopathy
Clair A. Booth,Jonathan Witton,Jakub Nowacki,Krasimira Tsaneva-Atanasova,Matt Jones,Andrew D. Randall,J Brown +6 more
TL;DR: The results show that tau pathology is associated with specific disturbances in synaptic, cellular, and network-level function, culminating in the aberrant encoding of spatial information and spatial memory impairment in hippocampus.
Journal ArticleDOI
Clinical features of frontotemporal dementia due to the intronic tau 10(+16) mutation
JC Janssen,Elizabeth K. Warrington,Huw R. Morris,Peter L. Lantos,J Brown,T Revesz,Nicola Wood,M. N. Khan,Lisa Cipolotti,Nick C. Fox,Martin N. Rossor +10 more
TL;DR: There was considerable variation in age at onset and duration of disease both between and within families, suggesting the presence of an effect due to other genetic or environmental factors.
Journal ArticleDOI
Molecular genetic characterisation of frontotemporal dementia on chromosome 3.
Alan Ashworth,Sarah E. Lloyd,J Brown,Susanne Gydesen,Sven Asger Sørensen,A Brun,Elisabet Englund,C. Humphreys,David E. Housman,M. Badura,Vincent P. Stanton,K. Taylor,J. Cameron,D. Munroe,J. Johansson,Martin N. Rossor,Elizabeth M. C. Fisher,John Collinge +17 more
TL;DR: A locus causing familial nonspecific dementia to the centromeric region of chromosome 3 in a pedigree from the Jutland area of Denmark shows anticipation which is suggestive of trinucleotide repeat expansion involvement, and strategies to clone the mutant gene via its putative associated trinuclear repeat sequence are outlined.