Fiorella Belpoggi

TL;DR: APM is a multipotential carcinogenic agent, even at a daily dose of 20 mg/kg body weight, much less than the current acceptable daily intake, and a reevaluation of the present guidelines on the use and consumption of APM is urgent and cannot be delayed.

TL;DR: Under the tested experimental conditions, MTBE was shown to cause an increase in Leydig interstitial cell tumors of the testes and a dose-related increase in lymphomas and leukemias in female rats.

TL;DR: The Bologna experiments proved for the first time that benzene is an experimental carcinogen and indicated a clear-cut dose-response relationship in benzene carcinogenesis, and the need for more experimental research aimed at assessing the carcinogenic effects of low doses of Benzene, of chemical mixtures containing benzene, and of benzene substitutes is emphasized.

TL;DR: The results of this carcinogenicity bioassay confirm and reinforce the first experimental demonstration of APM’s multipotential carcinogensicity at a dose level close to the acceptable daily intake for humans.

TL;DR: The International Agency for Research on Cancer (IARC) Monographs Programme identifies chemicals, drugs, mixtures, occupational exposures, lifestyles and personal habits, and physical and biological agents that cause cancer in humans and has evaluated about 1000 agents since 1971.