Florian Aeschimann

TL;DR: P pervasive, large-amplitude, and phase-locked oscillations of gene expression in developing C. elegans larvae, caused by periodic transcription, are reported and ribosome profiling reveals that periodic mRNA accumulation causes rhythmic translation, potentially facilitating transient protein accumulation as well as coordinated production of stable, complex structures such as the cuticle.

TL;DR: The authors show that Gcn4 also acts as a repressor of protein biosynthesis in a range of conditions that enhance yeast lifespan, such as ribosomal protein knockout, calorie restriction or mTOR inhibition.

TL;DR: It is demonstrated that this RBP has two distinct mRNA-silencing activities, and such position-dependent dual activity may, when studied more systematically, emerge as a feature shared by other RBPs.

TL;DR: This work proposes Rp-Bp, an unsupervised Bayesian approach to predict translated ORFs from ribosome profiles using state-of-the-art Markov chain Monte Carlo techniques to estimate posterior distributions of the likelihood of translation of each ORF.

TL;DR: It is found that the timing of sexually dimorphic differentiation of postmitotic, sex-shared neurons in the nervous system of the Caenorhabditis elegans male is controlled by the temporally regulated miRNA let-7 and its target lin-41, a translational regulator.