L
Laura Pereira
Researcher at Howard Hughes Medical Institute
Publications - 9
Citations - 445
Laura Pereira is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Nervous system & Cholinergic. The author has an hindex of 5, co-authored 9 publications receiving 350 citations. Previous affiliations of Laura Pereira include Columbia University.
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Journal ArticleDOI
A cellular and regulatory map of the cholinergic nervous system of C. elegans
Laura Pereira,Laura Pereira,Paschalis Kratsios,Paschalis Kratsios,Esther Serrano-Saiz,Esther Serrano-Saiz,Hila Sheftel,Avi Mayo,David H. Hall,John G. White,Brigitte LeBoeuf,L. Rene Garcia,L. Rene Garcia,Uri Alon,Oliver Hobert,Oliver Hobert +15 more
TL;DR: It is found that acetylcholine (ACh) is the most broadly used neurotransmitter and its usage relative to other neurotransmitters within the context of the entire connectome and within specific network motifs embedded in the connectome.
Journal ArticleDOI
A Neurotransmitter Atlas of the Caenorhabditis elegans Male Nervous System Reveals Sexually Dimorphic Neurotransmitter Usage.
Esther Serrano-Saiz,Laura Pereira,Marie Gendrel,Ulkar Aghayeva,Abhishek Bhattacharya,Kelly Howell,L. Rene Garcia,Oliver Hobert +7 more
TL;DR: A comprehensive atlas of neurotransmitters used in the nervous system of the male and compare it to that of the hermaphrodite is provided and exemplifies the usefulness of the neurotransmitter atlas by using it as a tool to define the expression pattern of a synaptic organizer molecule in the male tail.
Journal ArticleDOI
Timing mechanism of sexually dimorphic nervous system differentiation
Laura Pereira,Florian Aeschimann,Chen Wang,Hannah Lawson,Esther Serrano-Saiz,Douglas S. Portman,Helge Großhans,Helge Großhans,Oliver Hobert +8 more
TL;DR: It is found that the timing of sexually dimorphic differentiation of postmitotic, sex-shared neurons in the nervous system of the Caenorhabditis elegans male is controlled by the temporally regulated miRNA let-7 and its target lin-41, a translational regulator.
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Dopamine negatively modulates the NCA ion channels in C. elegans.
TL;DR: This study identifies a pathway by which dopamine modulates the activity of the NCA channels and demonstrates that dopamine, through DOP-3, negatively regulates NCA activity.
Journal ArticleDOI
Modular Organization of Cis-regulatory Control Information of Neurotransmitter Pathway Genes in Caenorhabditis elegans
Esther Serrano-Saiz,Esther Serrano-Saiz,Burcu Gulez,Laura Pereira,Marie Gendrel,Marie Gendrel,Sze Yen Kerk,Berta Vidal,Weidong Feng,Chen Wang,Paschalis Kratsios,James B. Rand,Oliver Hobert +12 more
TL;DR: It is found that the cellular specificity of expression of all of these genes is controlled in a modular manner through distinct cis-regulatory elements, corroborating the previously inferred piecemeal nature of specification of neurotransmitter identity.