F
Fotios Drenos
Researcher at Brunel University London
Publications - 119
Citations - 8978
Fotios Drenos is an academic researcher from Brunel University London. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 40, co-authored 110 publications receiving 7662 citations. Previous affiliations of Fotios Drenos include University College London & University of Newcastle.
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Journal ArticleDOI
Post-GWAS methodologies for localisation of functional non-coding variants: ANGPTL3.
Federico Oldoni,Federico Oldoni,Jutta Palmen,Claudia Giambartolomei,Philip N. Howard,Fotios Drenos,Vincent Plagnol,Steve E. Humphries,Philippa J. Talmud,Andrew J. Smith +9 more
TL;DR: This study illustrates the power of combining multiple genome-wide datasets with laboratory data to localise functional non-coding variation and provides a model for analysis of regulatory variants from GWAS.
Journal ArticleDOI
A genetic instrument for Mendelian randomization of fibrinogen
TL;DR: There is statistical evidence for several functional sites in the fibrinogen gene cluster that determine an individual’s plasma fibr inogen levels, and a combination of several SNPs will provide a stronger instrument for fibrInogen Mendelian randomization studies.
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Free Protein S Level as a Risk Factor for Coronary Heart Disease and Stroke in a Prospective Cohort Study of Healthy United Kingdom Men
TL;DR: This study confirms the independent association of elevated free PS levels with future risk of CHD, although elevated PS levels added only modestly to prediction metrics, and the novel finding of increased CHD risk, particularly when CRP and PS levels are high.
Journal ArticleDOI
Progress in genetic association studies of plasma lipids.
TL;DR: Genetic studies have identified many loci associated with plasma lipids and have provided insight into the underlying mechanisms of lipid homeostasis and future research is needed to determine whether these loci may be novel targets for lipid-lowering therapy and for reducing cardiovascular disease risk.
Journal ArticleDOI
Variant rs10911021 that associates with coronary heart disease in type 2 diabetes, is associated with lower concentrations of circulating HDL cholesterol and large HDL particles but not with amino acids
Katherine E. Beaney,Jackie A. Cooper,Stela McLachlan,S. Goya Wannamethee,Barbara J. Jefferis,Peter H. Whincup,Yoav Ben-Shlomo,Jacqueline F. Price,Meena Kumari,Meena Kumari,Andrew Wong,Ken K. Ong,Rebecca Hardy,Diana Kuh,Mika Kivimäki,Antti J. Kangas,Pasi Soininen,Pasi Soininen,Mika Ala-Korpela,Mika Ala-Korpela,Mika Ala-Korpela,Fotios Drenos,Fotios Drenos,Steve E. Humphries +23 more
TL;DR: The findings are consistent with a true association between rs10911021 and CHD in T2D and the protective minor allele was associated with lower HDL-cholesterol and reductions in HDL particle traits.