F
Fotios Drenos
Researcher at Brunel University London
Publications - 119
Citations - 8978
Fotios Drenos is an academic researcher from Brunel University London. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 40, co-authored 110 publications receiving 7662 citations. Previous affiliations of Fotios Drenos include University College London & University of Newcastle.
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Journal ArticleDOI
Integration of genetics into a systems model of electrocardiographic traits using humancvd beadchip
Tom R. Gaunt,Sonia Shah,Christopher P. Nelson,Fotios Drenos,Peter S. Braund,Ismail Adeniran,Lasse Folkersen,Debbie A Lawlor,Juan-Pablo Casas,Antoinette Amuzu,Mika Kivimäki,John C. Whittaker,Per Eriksson,Henggui Zhang,Jules C. Hancox,Maciej Tomaszewski,Paul Burton,Martin D. Tobin,Steve E. Humphries,Philippa J. Talmud,Peter W. Macfarlane,Aroon D. Hingorani,Nilesh J. Samani,Meena Kumari,Ian N. M. Day +24 more
TL;DR: These association results replicate and refine the mapping of previous genome-wide association study findings for electrocardiographic traits, while the expression analysis and modeling approaches offer supporting evidence for a functional role of some of these loci in cardiac excitation/conduction.
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Genetic meta-analysis of 15,901 African Americans identifies variation in EXOC3L1 is associated with HDL concentration.
Matthew B. Lanktree,Clara C. Elbers,Clara C. Elbers,Yun Li,Guosheng Zhang,Qing Duan,Konrad J. Karczewski,Konrad J. Karczewski,Yiran Guo,Vinicius Tragante,Kari E. North,Mary Cushman,Folkert W. Asselbergs,James G. Wilson,Leslie A. Lange,Fotios Drenos,Alexander P. Reiner,Michael R. Barnes,Brendan J. Keating +18 more
TL;DR: Increasing sample sizes for genetic studies in nonEuropean populations will continue to improve the understanding of lipid metabolism, andMeta-analyses of European populations has successfully identified genetic variants in over 150 loci associated with lipid levels, but results from additional ethnicities remain limited.
Journal ArticleDOI
Identifying gene-gene interactions that are highly associated with four quantitative lipid traits across multiple cohorts.
Rishika De,Shefali S. Verma,Emily R. Holzinger,Molly A. Hall,Amber A. Burt,David Carrell,David R. Crosslin,Gail P. Jarvik,Helena Kuivaniemi,Iftikhar J. Kullo,Leslie A. Lange,Matthew B. Lanktree,Eric B. Larson,Kari E. North,Alexander P. Reiner,Vinicius Tragante,Gerard Tromp,James G. Wilson,Folkert W. Asselbergs,Fotios Drenos,Fotios Drenos,Jason H. Moore,Marylyn D. Ritchie,Brendan J. Keating,Brendan J. Keating,Diane Gilbert-Diamond +25 more
TL;DR: This study combined the use of the quantitative multifactor dimensionality reduction (QMDR) algorithm with two SNP-filtering methods to exhaustively search for SNP–SNP interactions that are associated with HDL cholesterol, LDL cholesterol,LDL-C, total cholesterol, TC and triglycerides.
Journal ArticleDOI
A genetic risk score is associated with statin-induced low-density lipoprotein cholesterol lowering
Maarten Leusink,Anke H. Maitland-van der Zee,Bo Ding,Fotios Drenos,Fotios Drenos,Erik P A Van Iperen,Helen R. Warren,Mark J. Caulfield,L. Adrienne Cupples,L. Adrienne Cupples,Mary Cushman,Aroon D. Hingorani,Ron C. Hoogeveen,G. Kees Hovingh,Meena Kumari,Leslie A. Lange,Patricia B. Munroe,Fredrik Nyberg,Fredrik Nyberg,Pamela J. Schreiner,Suthesh Sivapalaratnam,Paul I.W. de Bakker,Anthonius de Boer,Brendan J. Keating,Folkert W. Asselbergs,Folkert W. Asselbergs,N. Charlotte Onland-Moret +26 more
TL;DR: The GRS was associated with statin response, but the small effect size (˜2% of the average low-density lipoprotein cholesterol reduction) limits applicability.
Journal ArticleDOI
Assessment of the clinical utility of adding common single nucleotide polymorphism genetic scores to classical risk factor algorithms in coronary heart disease risk prediction in UK men.
TL;DR: The 19-SNP GS is robustly associated with CHD and showed potential clinical utility in the UK population and the inclusion of genetic risk may improve their performance.