F
Fotios Drenos
Researcher at Brunel University London
Publications - 119
Citations - 8978
Fotios Drenos is an academic researcher from Brunel University London. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 40, co-authored 110 publications receiving 7662 citations. Previous affiliations of Fotios Drenos include University College London & University of Newcastle.
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Journal ArticleDOI
Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension
Praveen Surendran,Fotios Drenos,Robin Young,Helen R. Warren,James P. Cook,Alisa K. Manning,Niels Grarup,Xueling Sim,Daniel R. Barnes,Kate Witkowska,James R Staley,Vinicius Tragante,Taru Tukiainen,Hanieh Yaghootkar,Nicholas Masca,Daniel F. Freitag,Teresa Ferreira,Olga Giannakopoulou,Andrew Tinker,Magdalena Harakalova,Evelin Mihailov,Chunyu Liu,Aldi T. Kraja,Sune F. Nielsen,Asif Rasheed,Maria Samuel,Wei Zhao,Lori L. Bonnycastle,Anne U. Jackson,Narisu Narisu,Amy J. Swift,Lorraine Southam,Jonathan Marten,Jeroen R. Huyghe,Alena Stančáková,Cristiano Fava,Therese Ohlsson,Angela Matchan,Kathleen Stirrups,Jette Bork-Jensen,Anette P. Gjesing,Jukka Kontto,Markus Perola,Susan Shaw-Hawkins,Aki S. Havulinna,He Zhang,Louise A. Donnelly,Christopher J. Groves,N. William Rayner,Matt Neville,Neil R. Robertson,Andrianos M. Yiorkas,Karl-Heinz Herzig,Eero Kajantie,Weihua Zhang,Sara M. Willems,Lars Lannfelt,Giovanni Malerba,Nicole Soranzo,Elisabetta Trabetti,Niek Verweij,Evangelos Evangelou,Alireza Moayyeri,Anne-Claire Vergnaud,Christopher P. Nelson,Alaitz Poveda,Tibor V. Varga,Muriel J. Caslake,Anton J. M. de Craen,Stella Trompet,Jian'an Luan,Robert A. Scott,Sarah E. Harris,David C. Liewald,Riccardo E. Marioni,Cristina Menni,Aliki-Eleni Farmaki,Göran Hallmans,Frida Renström,Jennifer E. Huffman,Maija Hassinen,Stephen Burgess,Ramachandran S. Vasan,Janine F. Felix,Maria Uria-Nickelsen,Anders Mälarstig,Dermot F. Reilly,Maarten Hoek,Thomas F. Vogt,Honghuang Lin,Wolfgang Lieb,Matthew Traylor,Hugh S. Markus,Heather M. Highland,Anne E. Justice,Eirini Marouli,Jaana Lindström,Matti Uusitupa,Pirjo Komulainen,Timo A. Lakka,Rainer Rauramaa,Ozren Polasek,Igor Rudan,Olov Rolandsson,Paul W. Franks,George Dedoussis,Tim D. Spector,Pekka Jousilahti,Satu Männistö,Ian J. Deary,John M. Starr,Claudia Langenberg,Nicholas J. Wareham,Morris Brown,Anna F. Dominiczak,John M. C. Connell,J. Wouter Jukema,Naveed Sattar,Ian Ford,Chris J. Packard,Tõnu Esko,Reedik Mägi,Andres Metspalu,Rudolf A. de Boer,Peter van der Meer,Pim van der Harst,Giovanni Gambaro,Erik Ingelsson,Lars Lind,Paul I.W. de Bakker,Mattijs E. Numans,Ivan Brandslund,Cramer Christensen,Eva Rabing Brix Petersen,Eeva Korpi-Hyövälti,Heikki Oksa,John C. Chambers,Jaspal S. Kooner,Alexandra I. F. Blakemore,Steve Franks,Marjo-Riitta Järvelin,Lise Lotte N. Husemoen,Allan Linneberg,Tea Skaaby,Betina H. Thuesen,Fredrik Karpe,Jaakko Tuomilehto,Alex S. F. Doney,Andrew D. Morris,Colin N. A. Palmer,Oddgeir L. Holmen,Kristian Hveem,Cristen J. Willer,Tiinamaija Tuomi,Leif Groop,Annemari Käräjämäki,Aarno Palotie,Samuli Ripatti,Veikko Salomaa,Dewan S. Alam,Abdulla Al Shafi Majumder,Emanuele Di Angelantonio,Rajiv Chowdhury,Mark I. McCarthy,Neil Poulter,Alice Stanton,Peter S. Sever,Philippe Amouyel,Dominique Arveiler,Stefan Blankenberg,Jean Ferrières,Frank Kee,Kari Kuulasmaa,Martina Müller-Nurasyid,Giovanni Veronesi,Jarmo Virtamo,Panos Deloukas,Paul Elliott,Eleftheria Zeggini,Sekar Kathiresan,Olle Melander,Johanna Kuusisto,Markku Laakso,Sandosh Padmanabhan,David J. Porteous,Caroline Hayward,Generation Scotland,Francis S. Collins,Karen L. Mohlke,Torben Hansen,Oluf Pedersen,Michael Boehnke,Heather M. Stringham,Philippe M. Frossard,Christopher Newton-Cheh,Martin D. Tobin,Børge G. Nordestgaard,Mark J. Caulfield,Anubha Mahajan,Andrew P. Morris,Maciej Tomaszewski,Nilesh J. Samani,Danish Saleheen,Folkert W. Asselbergs,Cecilia M. Lindgren,John Danesh,Louise V. Wain,Adam S. Butterworth,Joanna M. M. Howson,Patricia B. Munroe +209 more
TL;DR: Thirty new blood pressure– or hypertension-associated genetic regions in the general population are identified, including 3 rare missense variants in RBM47, COL21A1 and RRAS with larger effects than common variants.
Journal ArticleDOI
Large-Scale Gene-Centric Meta-analysis across 32 Studies Identifies Multiple Lipid Loci
Folkert W. Asselbergs,Yiran Guo,Yiran Guo,Erik P A Van Iperen,Suthesh Sivapalaratnam,Vinicius Tragante,Matthew B. Lanktree,Leslie A. Lange,Berta Almoguera,Yolande Appelman,John Barnard,Jens Baumert,Amber L. Beitelshees,Tushar Bhangale,Yii-Der Ida Chen,Tom R. Gaunt,Yan Gong,Jemma C. Hopewell,Toby Johnson,Marcus E. Kleber,Taimour Y. Langaee,Mingyao Li,Yun Li,Kiang Liu,Caitrin W. McDonough,Matthijs F.L. Meijs,Rita P.S. Middelberg,Kiran Musunuru,Kiran Musunuru,Christopher P. Nelson,Jeffery R. O'Connell,Sandosh Padmanabhan,James S. Pankow,Nathan Pankratz,Suzanne Rafelt,Ramakrishnan Rajagopalan,Simon P. R. Romaine,Nicholas J. Schork,Jonathan A. Shaffer,Haiqing Shen,Erin N. Smith,Sam E. Tischfield,Peter J. van der Most,Jana V. van Vliet-Ostaptchouk,Niek Verweij,Kelly A. Volcik,Li Zhang,Kent R. Bailey,Kristian M. Bailey,Florianne Bauer,Jolanda M. A. Boer,Peter S. Braund,Amber A. Burt,Paul Burton,Sarah G. Buxbaum,Wei Chen,Rhonda M. Cooper-DeHoff,L. Adrienne Cupples,L. Adrienne Cupples,Jonas S. Dejong,Christian Delles,David Duggan,Myriam Fornage,Clement E. Furlong,Nicole L. Glazer,John G. Gums,Claire E. Hastie,Michael V. Holmes,Thomas Illig,Susan Kirkland,Mika Kivimäki,Ronald Klein,Barbara E.K. Klein,Charles Kooperberg,Kandice Kottke-Marchant,Meena Kumari,Andrea Z. LaCroix,Laya Mallela,Gurunathan Murugesan,Jose M. Ordovas,Willem H. Ouwehand,Wendy S. Post,Richa Saxena,Richa Saxena,Hubert Scharnagl,Pamela J. Schreiner,Tina Shah,Denis C. Shields,Daichi Shimbo,Sathanur R. Srinivasan,Ronald P. Stolk,Daniel I. Swerdlow,Herman A. Taylor,Eric J. Topol,Elina Toskala,Joost L. Van Pelt,Jessica van Setten,Salim Yusuf,John C. Whittaker,John C. Whittaker,A. H. Zwinderman,Sonia S. Anand,Anthony J. Balmforth,Gerald S. Berenson,Connie R. Bezzina,Connie R. Bezzina,Bernhard O. Boehm,Eric Boerwinkle,Juan P. Casas,Juan P. Casas,Mark J. Caulfield,Robert Clarke,John M. C. Connell,Karen J. Cruickshanks,Karina W. Davidson,Ian N. M. Day,Paul I.W. de Bakker,Paul I.W. de Bakker,Paul I.W. de Bakker,Pieter A. Doevendans,Anna F. Dominiczak,Alistair S. Hall,Catharina A. Hartman,Christian Hengstenberg,Hans L. Hillege,Marten H. Hofker,Steve E. Humphries,Gail P. Jarvik,Julie A. Johnson,Bernhard M. Kaess,Sekar Kathiresan,Sekar Kathiresan,Wolfgang Koenig,Debbie A Lawlor,Winfried März,Winfried März,Olle Melander,Braxton D. Mitchell,Grant W. Montgomery,Patricia B. Munroe,Sarah S. Murray,Stephen Newhouse,N. Charlotte Onland-Moret,Neil R Poulter,Bruce M. Psaty,Bruce M. Psaty,Susan Redline,Stephen S. Rich,Jerome I. Rotter,Heribert Schunkert,Peter Sever,Alan R. Shuldiner,Alan R. Shuldiner,Roy L. Silverstein,Alice V. Stanton,Alice V. Stanton,Barbara Thorand,Mieke D. Trip,Michael Y. Tsai,Pim van der Harst,Ellen Van Der Schoot,Yvonne T. van der Schouw,W. M. Monique Verschuren,Hugh Watkins,Arthur A.M. Wilde,Bruce H. R. Wolffenbuttel,John Whitfield,G. Kees Hovingh,Christie M. Ballantyne,Cisca Wijmenga,Muredach P. Reilly,Nicholas G. Martin,James G. Wilson,Daniel J. Rader,Nilesh J. Samani,Nilesh J. Samani,Alexander P. Reiner,Robert A. Hegele,John J.P. Kastelein,Aroon D. Hingorani,Philippa J. Talmud,Hakon Hakonarson,Clara C. Elbers,Brendan J. Keating,Fotios Drenos +184 more
TL;DR: This large meta-analysis of lipid phenotypes with the use of a dense gene-centric approach identified multiple SNPs not previously described in established lipid genes and several previously unknown loci, suggesting that a focused genotyping approach can further increase the understanding of heritability of plasma lipids.
Journal ArticleDOI
Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci
Chunyu Liu,Aldi T. Kraja,Jennifer A. Smith,Jennifer A. Brody,Nora Franceschini,Joshua C. Bis,Kenneth Rice,Alanna C. Morrison,Yingchang Lu,Stefan Weiss,Xiuqing Guo,Walter Palmas,Lisa W. Martin,Yii-Der Ida Chen,Praveen Surendran,Fotios Drenos,Fotios Drenos,James P. Cook,James P. Cook,Paul L. Auer,Audrey Y. Chu,Ayush Giri,Wei Zhao,Johanna Jakobsdottir,Li-An Lin,Jeanette M. Stafford,Najaf Amin,Hao Mei,Jie Yao,Arend Voorman,Martin G. Larson,Megan L. Grove,Albert V. Smith,Shih-Jen Hwang,Han Chen,Tianxiao Huan,Gulum Kosova,Gulum Kosova,Nathan O. Stitziel,Sekar Kathiresan,Sekar Kathiresan,Nilesh J. Samani,Nilesh J. Samani,Heribert Schunkert,Panos Deloukas,Panos Deloukas,Man Li,Christian Fuchsberger,Cristian Pattaro,Mathias Gorski,Charles Kooperberg,George J. Papanicolaou,Jacques E. Rossouw,Jessica D. Faul,Sharon L.R. Kardia,Claude Bouchard,Leslie J. Raffel,André G. Uitterlinden,Oscar H. Franco,Ramachandran S. Vasan,Christopher J. O'Donnell,Kent D. Taylor,Kiang Liu,Erwin P. Bottinger,Omri Gottesman,E. Warwick Daw,Franco Giulianini,Santhi K. Ganesh,Elias Salfati,Tamara B. Harris,Lenore J. Launer,Marcus Dörr,Stephan B. Felix,Rainer Rettig,Henry Völzke,Eric Kim,Wen-Jane Lee,Wen-Jane Lee,I-Te Lee,Wayne H-H Sheu,Krystal S Tsosie,Digna R. Velez Edwards,Yongmei Liu,Adolfo Correa,David R. Weir,Uwe Völker,Uwe Völker,Paul M. Ridker,Eric Boerwinkle,Vilmundur Gudnason,Alexander P. Reiner,Cornelia M. van Duijn,Ingrid B. Borecki,Todd L. Edwards,Aravinda Chakravarti,Jerome I. Rotter,Bruce M. Psaty,Ruth J. F. Loos,Myriam Fornage,Myriam Fornage,Georg Ehret,Georg Ehret,Christopher Newton-Cheh,Daniel Levy,Daniel Levy,Daniel I. Chasman +105 more
TL;DR: This large collection of blood pressure–associated loci suggests new therapeutic strategies for hypertension, emphasizing a link with cardiometabolic risk.
Journal ArticleDOI
Gene-centric Association Signals for Lipids and Apolipoproteins Identified via the HumanCVD BeadChip
Philippa J. Talmud,Fotios Drenos,Sonia Shah,Tina Shah,Jutta Palmen,Claudio J. Verzilli,Tom R. Gaunt,Jacky Pallas,Ruth C. Lovering,KaWah Li,Juan P. Casas,Reecha Sofat,Meena Kumari,Santiago Rodriguez,Toby Johnson,Stephen Newhouse,Anna F. Dominiczak,Nilesh J. Samani,Mark J. Caulfield,Peter S. Sever,Alice Stanton,Denis C. Shields,Sandosh Padmanabhan,Olle Melander,Claire E. Hastie,Christian Delles,Shah Ebrahim,Michael Marmot,George Davey Smith,Debbie A Lawlor,Patricia B. Munroe,Ian N. M. Day,Mika Kivimäki,John C. Whittaker,Steve E. Humphries,Aroon D. Hingorani +35 more
TL;DR: The Whitehall II study identified 195 SNPs in 16 genes/regions associated with 3 major lipid fractions and 2 apolipoprotein components at p<10(-5), with the associations being broadly concordant with prior genome-wide analysis.
Journal ArticleDOI
Blood Pressure Loci Identified with a Gene-Centric Array
Toby Johnson,Tom R. Gaunt,Stephen Newhouse,Stephen Newhouse,Sandosh Padmanabhan,Marciej Tomaszewski,Marciej Tomaszewski,Meena Kumari,Richard W Morris,Ioanna Tzoulaki,Ioanna Tzoulaki,Eoin O'Brien,Neil R Poulter,Peter S. Sever,Denis C. Shields,Simon A. McG. Thom,SG Wannamethee,Peter H. Whincup,Morris J. Brown,John M. C. Connell,Richard Dobson,Philip Howard,Charles A. Mein,Abiodun Onipinla,Sue Shaw-Hawkins,Yun Zhang,George Davey Smith,Ian N M Day,Debbie A Lawlor,Alison H. Goodall,Alison H. Goodall,F. Gerald R. Fowkes,Gonçalo R. Abecasis,Paul Elliott,Paul Elliott,Vesela Gateva,Peter S. Braund,Peter S. Braund,Paul Burton,Paul Burton,Christopher P. Nelson,Christopher P. Nelson,Martin D. Tobin,Pim van der Harst,Nicola Glorioso,Hani Neuvrith,Erika Salvi,Jan A. Staessen,Andrea Stucchi,Nabila Devos,Xavier Jeunemaitre,Xavier Jeunemaitre,Pierre-François Plouin,Pierre-François Plouin,Jean Tichet,Peeter Juhanson,Elin Org,Margus Putku,Siim Sõber,Gudrun Veldre,Margus Viigimaa,Anna Levinsson,Annika Rosengren,Dag S. Thelle,Claire E. Hastie,Thomas Hedner,Wai K. Lee,Olle Melander,Björn Wahlstrand,Rebecca Hardy,Andrew Wong,Jackie A. Cooper,Jutta Palmen,Li Chen,Alexandre F.R. Stewart,George A. Wells,Harm-Jan Westra,Marcel G. M. Wolfs,Robert Clarke,Maria Grazia Franzosi,Anuj Goel,Anuj Goel,Anders Hamsten,Mark Lathrop,John F. Peden,John F. Peden,Udo Seedorf,Hugh Watkins,Hugh Watkins,Willem H. Ouwehand,Willem H. Ouwehand,Jennifer G. Sambrook,Jonathan Stephens,Juan-Pablo Casas,Juan-Pablo Casas,Fotios Drenos,Michael V. Holmes,Mika Kivimäki,Sonia Shah,Tina Shah,Philippa J. Talmud,John C. Whittaker,John C. Whittaker,Chris Wallace,Christian Delles,Maris Laan,Diana Kuh,Steve E. Humphries,Fredrik Nyberg,Fredrik Nyberg,Daniele Cusi,Robert Roberts,Christopher Newton-Cheh,Lude Franke,Alive V. Stanton,Anna F. Dominiczak,Martin Farrall,Martin Farrall,Aroon D. Hingorani,Nilesh J. Samani,Nilesh J. Samani,Mark J. Caulfield,Patricia B. Munroe +122 more
TL;DR: An analysis of combined discovery and follow-up data identified SNPs significantly associated with BP at p < 8.56 × 10(-7) at four further loci and highlighted the utility of studying SNPs and samples that are independent of those studied previously even when the sample size is smaller than that in previous studies.