F
Fotios Drenos
Researcher at Brunel University London
Publications - 119
Citations - 8978
Fotios Drenos is an academic researcher from Brunel University London. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 40, co-authored 110 publications receiving 7662 citations. Previous affiliations of Fotios Drenos include University College London & University of Newcastle.
Papers
More filters
Journal ArticleDOI
Angiotensin-Converting Enzyme Genotype and Successful Ascent to Extreme High Altitude
Julian Thompson,James Raitt,Lynn Hutchings,Fotios Drenos,Eirik Bjargo,Are Loset,Michael P.W. Grocott,Hugh Montgomery +7 more
TL;DR: This study demonstrates an association between the ACE I-allele and successful ascent to over 8000 m.
Journal ArticleDOI
Metabolic signatures of birthweight in 18 288 adolescents and adults.
Peter Würtz,Qin Wang,Qin Wang,Marjo Niironen,Marjo Niironen,Tuulia Tynkkynen,Tuulia Tynkkynen,Mika Tiainen,Mika Tiainen,Fotios Drenos,Antti J. Kangas,Pasi Soininen,Pasi Soininen,Michael R. Skilton,Kauko Heikkilä,Anneli Pouta,Anneli Pouta,Mika Kähönen,Terho Lehtimäki,Richard J. Rose,Eero Kajantie,Eero Kajantie,Eero Kajantie,Markus Perola,Markus Perola,Jaakko Kaprio,Jaakko Kaprio,Johan G. Eriksson,Olli T. Raitakari,Olli T. Raitakari,Debbie A Lawlor,George Davey Smith,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Mika Ala-Korpela,Kirsi Auro,Kirsi Auro +36 more
TL;DR: Lower birthweight adjusted for gestational age was adversely associated with cardiometabolic biomarkers, including lipoprotein subclasses, fatty acids, amino acids and markers of inflammation and impaired liver function, suggesting birthweight is only a weak indicator of the metabolic risk profile in adulthood.
Journal ArticleDOI
Population Genomics of Cardiometabolic Traits: Design of the University College London-London School of Hygiene and Tropical Medicine-Edinburgh-Bristol (UCLEB) Consortium
Tina Shah,Jorgen Engmann,Caroline Dale,Sonia Shah,Jon White,Claudia Giambartolomei,Stela McLachlan,Delilah Zabaneh,Alana Cavadino,Chris Finan,Andrew Wong,Antoinette Amuzu,Ken K. Ong,Tom R. Gaunt,Michael V. Holmes,Helen R. Warren,Teri-Louise Davies,Fotios Drenos,Jackie A. Cooper,Reecha Sofat,Mark J. Caulfield,Shah Ebrahim,Debbie A Lawlor,Philippa J. Talmud,Steve E. Humphries,Christine Power,Elina Hyppönen,Marcus Richards,Rebecca Hardy,Diana Kuh,Nicholas J. Wareham,Yoav Ben-Shlomo,Ian N. M. Day,Peter H. Whincup,Richard W Morris,Mark W. J. Strachan,Jacqueline F. Price,Meena Kumari,Mika Kivimäki,Vincent Plagnol,Frank Dudbridge,John C. Whittaker,Juan P. Casas,Juan P. Casas,Aroon D. Hingorani +44 more
TL;DR: The UCLEB consortium of highly-phenotyped population-based prospective studies aims to precisely estimate individual absolute and population attributable risks based on individual SNPs and their combination and use Mendelian randomisation to undertake studies of the causal role in CVD of a range of cardiovascular biomarkers to inform public health policy and help develop new preventative therapies.
Journal ArticleDOI
Variants of ADRA2A are associated with fasting glucose, blood pressure, body mass index and type 2 diabetes risk: meta-analysis of four prospective studies
P.J. Talmud,J.A. Cooper,Tom R. Gaunt,Michael V. Holmes,Sonia Shah,Jutta Palmen,Fotios Drenos,Tina Shah,Meena Kumari,Mika Kivimäki,John C. Whittaker,Debbie A Lawlor,Ian N. M. Day,Aroon D. Hingorani,Juan P. Casas,Juan P. Casas,Steve E. Humphries +16 more
TL;DR: Multiple ADRA2A SNPs are associated with metabolic traits, blood pressure and type 2 diabetes risk and the α-2 adrenergic receptor should be revisited as a therapeutic target for reduction of the adverse consequences of metabolic trait disorders and type 1 diabetes.
Journal ArticleDOI
Causal Relevance of Blood Lipid Fractions in the Development of Carotid Atherosclerosis: Mendelian Randomization Analysis
Sonia Shah,Juan-Pablo Casas,Fotios Drenos,John C. Whittaker,John E. Deanfield,Daniel I. Swerdlow,Michael V. Holmes,Mika Kivimäki,Claudia Langenberg,Nicholas J. Wareham,Karl Gertow,Bengt Sennblad,Rona J. Strawbridge,Damiano Baldassarre,Fabrizio Veglia,Elena Tremoli,Bruna Gigante,Ulf de Faire,Meena Kumari,Philippa J. Talmud,Anders Hamsten,Steve E. Humphries,Aroon D. Hingorani +22 more
TL;DR: In this paper, the causal relationship between low-density lipoprotein cholesterol and Carotid intima-media thickness (CIMT), a subclinical measure of atherosclerosis, is associated with risk of coronary heart disease events.