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Fotios Drenos
Researcher at Brunel University London
Publications - 119
Citations - 8978
Fotios Drenos is an academic researcher from Brunel University London. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 40, co-authored 110 publications receiving 7662 citations. Previous affiliations of Fotios Drenos include University College London & University of Newcastle.
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Journal Article
Clinical Utility of a Coronary Heart Disease Risk Prediction Gene Score in UK Healthy Middle Aged Men and in the Pakistani Population (vol 10, e0130754, 2015)
Katherine E. Beaney,Jackie A. Cooper,Saleem Ullah Shahid,Waqas Ahmed,Raheel Qamar,Fotios Drenos,Martin Crockard,Steve E. Humphries +7 more
TL;DR: The performance of both GSs showed potential clinical utility in European men but much less utility in subjects from Pakistan, suggesting that a different set of risk loci or SNPs may be required for risk prediction in the South Asian population.
Journal ArticleDOI
The Lichfield bone study: the skeletal response to exercise in healthy young men.
Kyriacos I. Eleftheriou,Jaikirty S. Rawal,A Kehoe,L James,John R. Payne,James R. A. Skipworth,Zudin Puthucheary,Fotios Drenos,Dudley J. Pennell,Mike Loosemore,Steve E. Humphries,Fares S. Haddad,Hugh Montgomery +12 more
TL;DR: It is shown, for the first time, that short-term exercise training in young men is associated not only with a rise in human femoral BMD, but also in femoral bone volume, the latter largely through a periosteal response.
Journal ArticleDOI
Haplotype and genotype effects of the F7 gene on circulating factor VII, coagulation activation markers and incident coronary heart disease in UK men.
Gie Ken-Dror,Fotios Drenos,Steve E. Humphries,Philippa J. Talmud,Aroon D. Hingorani,Mika Kivimäki,Meena Kumari,Kenneth A. Bauer,James H. Morrissey,Helen Ireland +9 more
TL;DR: The haplotype associated with low FVIIc level, with particularly reduced functional activity, was consistently associated with increased risk for CHD, whereas the haplotypes associated with high F VIIc level was not.
Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution
Anne E. Justice,Tugce Karaderi,Heather M. Highland,Kristin L. Young,Mariaelisa Graff,Yingchang Lu,Valérie Turcot,Paul L. Auer,Rebecca S. Fine,Xiuqing Guo,Claudia Schurmann,Adelheid Lempradl,Eirini Marouli,Anubha Mahajan,Thomas W. Winkler,Adam E. Locke,Carolina Medina-Gomez,Tõnu Esko,Sailaja Vedantam,Ayush Giri,Ken Sin Lo,Tamuno Alfred,Poorva Mudgal,Maggie C.Y. Ng,Nancy L. Heard-Costa,Mary F. Feitosa,Alisa K. Manning,Sara M. Willems,Suthesh Sivapalaratnam,Gonçalo R. Abecasis,Dewan S. Alam,Matthew A. Allison,Philippe Amouyel,Zorayr Arzumanyanm,Beverley Balkau,Lisa Bastarache,Sven Bergmann,Lawrence F. Bielak,Matthias Blueher,Michael Boehnke,Heiner Boeing,Eric Boerwinkle,Carsten A. Boeger,Jette Bork-Jensen,Erwin P. Bottinger,Donald W. Bowden,Ivan Brandslund,Linda Broer,Amber A. Burt,Adam S. Butterworth,Markj Caulfield,Giancarlo Cesana,John C. Chambers,Chasman, Daniel, I,Yii-Der Ida Chen,Rajiv Chowdhury,Cramer Christensen,Audreyy Chu,Francis S. Collins,James P. Cook,Amanda J. Cox,David S. Crosslin,John Danesh,Paul I. W. de Bakker,Simon de Denus,Renée de Mutsert,George Dedoussis,Ellen W. Demerath,Joe Dennis,Josh C. Denny,Emanuele Di Angelantonio,Marcus Doerr,Fotios Drenos,Marie-Pierre Dubé,Alison M. Dunning,Douglas F. Easton,Paul Elliott,Evangelos Evangelou,Aliki-Eleni Farmaki,Shuang Feng,Ele Ferrannini,Jean Ferrières,Jose C. Florez,Myriam Fornage,Caroline S. Fox,Paul W. Franks,Nele Friedrich,Wei Gan,Ilaria Gandin,Paolo Gasparini,Vilmantas Giedraitis,Giorgia Girotto,Mathias Gorski,Harald Grallert,Niels Grarup,Megan L. Groves,Stefan Gustafsson,Jeffrey Haessler,Torben Hansen,Andrew T. Hattersley,Caroline Hayward,Iris M. Heid,Oddgeir L. Holmen,G. Kees Hovingh,Joanna M. M. Howson,Yao Hu,Yi-Jen Hung,Kristian Hveem,M. Arfan Ikram,Erik Ingelsson,Anne U. Jackson,Gail P. Jarvik,Yucheng Jia,Torben Jørgensen,Pekka Jousilahti,Johanne Marie Justesen,Bratati Kahali,Maria Karaleftheri,Sharon L.R. Kardia,Fredrik Karpe,Frank Kee,Hidetoshi Kitajima,Pirjo Komulainen,Jaspal S. Kooner,Peter Kovacs,Bernhard K. Kraemer,Kari Kuulasmaa,Johanna Kuusisto,Markku Laakso,Timo A. Lakka,David Lamparter,Leslie A. La Nge,Claudia Langenberg,Eric B. Larson,Nanette R. Lee,Wen-Jane Lee,Terho Lehtimaeki,Cora E. Lewis,Huaixing Li,Jin Li,RuifangLi-Gao,Li-An Lin,Xu Lin,Lars Lind,Jaana Lindstroem,Allan Linneberg,Ching-Ti Liu,Dajiang J. Liu,Jian'an Luan,Leo-Pekka Lyytikäinen,Stuart MacGregor,Reedik Mägi,Satu Männistö,Gaëlle Marenne,Jonathan Marten,Nicholas G. D. Mascal,McCarthy, Mark, I,Karina Meidtner,Evelin Mihailov,Leena Moilanen,Marie Moitry,Dennis O. Mook-Kanamori,Anna Morgan,Andrew P. Morris,Martina Mueller-Nurasyid,Patricia B. Munroe,Narisu Narisu,Christopher P. Nelson,Matt J. Neville,Ioanna Ntalla,Katharine R. Owen,Oluf Pedersen,Gina M. Peloso,Craig E. Pennell,Markus Perola,Allan James,John R. B. Perry,Tune H. Pers,Ailith Ewing,Ozren Polasek,Asif Rasheed,Chelsea K. Raulerson,Rainer Rauramaa,Dermot F. Reilly,Alex P. Reiner,Paul M. Ridker,Manuel A. Rivas,Neil R. Robertson,Antonietta Robino,Igor Rudan,Katherine S. Ruth,Danish Saleheen,Veikko Salomaa,Nilesh J. Samani,Pamela J. Schreiner,Matthias B. Schulze,Robert A. Scott,Marcelo P. Segura-Lepe,Xueling Sim,Andrew J. Slater,Kerrin S. Small,Blair H. Smith,Jennifer A. Smith,Lorraine Southam,Tim D. Spector,Elizabeth K. Speliotes,Kari Stefansson,Valgerdur Steinthorsdottir,Kathleen Stirrups,Konstantin Strauch,Heather M. Stringham,Michael Stumvoll,Liang Sun,Praveen Surendran,Karin M. A. Swart,Jean-Claude Tardif,Kent D. Taylor,Alexander Teumer,Deborah J. Thompson,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Betina H. Thuesen,Anke Toenjes,Mina Torres,Emmanouil Tsafantakis,Jaakko Tuomilehto,André G. Uitterlinden,Matti Uusitupa,Cornelia M. van Duijn,Mauno Vanhala,Rohit Varma,Sita H. Vermeulen,Henrik Vestergaard,Veronique Vitart,Thomas F. Vogt,Dragana Vuckovic,Lynne E. Wagenknecht,Mark Walker,Lars Wallentin,Feijie Wang,Carol A. Wang,Shuai Wang,N. Icholas J. Wareham,Helen R. Warren,Dawn M. Waterworth,Jennifer Wessel,Harvey D. White,Cristen J. Willer,James G. Wilson,Andrew R. Wood,Ying Wu,Hanieh Yaghootkar,Jie Yao,Laura M. Verges-Armstrong,Robin Young,Eleftheria Zeggini,Xiaowei Zhan,Weihua Zhang,Jing Hua Zhao,Wei Zhao,He Zheng,Wei Zhou,M. Carola Zillikens,Fernando Rivadeneira,Ingrid B. Borecki,J. Andrew Pospisilik,Panos Deloukas,Timothy M. Frayling,Guillaume Lettre,Karen L. Mohlke,Rotter, Jerome, I,Zoltán Kutalik,Joel N. Hirschhorn,L. Adrienne Cupples,Ruth J. F. Loos,Kari E. North,Cecilia M. Lindgren,Jeffrey R. O'Connell,Olli T. Raitakari,Leslie A. Lange,Andr G. Uitterlinden,Megan L. Grove,Nicholas G. D. Masca,Nicholas J. Wareham,Tnu Esko,Paul I.W. de Bakker,Mark J. Caulfield,Martina Mller-Nurasyid +287 more
TL;DR: A transancestral exome-wide association study for body-fat distribution identifies protein-coding variants that are significantly associated with waist-to-hip ratio adjusted for body mass index.
Journal ArticleDOI
Networks in Coronary Heart Disease Genetics As a Step towards Systems Epidemiology
TL;DR: It is proposed that novel, non-linear, and integrative epidemiological approaches are required to combine all available information, in order to truly translate the new advances in medical sciences to gains in preventive measures and patients care.