F
Francesc Balaguer
Researcher at University of Barcelona
Publications - 241
Citations - 8187
Francesc Balaguer is an academic researcher from University of Barcelona. The author has contributed to research in topics: Colorectal cancer & Cancer. The author has an hindex of 42, co-authored 194 publications receiving 6594 citations. Previous affiliations of Francesc Balaguer include Baylor University & Baylor University Medical Center.
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Journal ArticleDOI
Risk of Advanced Neoplasia in First-Degree Relatives with Colorectal Cancer: A Large Multicenter Cross-Sectional Study.
Enrique Quintero,Marta Carrillo,Maria-Liz Leoz,Joaquín Cubiella,Carla J. Gargallo,Angel Lanas,Luis Bujanda,Antonio Z. Gimeno-García,Manuel Hernández-Guerra,David Nicolás-Pérez,Inmaculada Alonso-Abreu,Juan Diego Morillas,Francesc Balaguer,Alfonso Muriel +13 more
TL;DR: Individuals having two FDR with colorectal cancer showed an increased risk of advanced neoplasia compared to those with average-risk for coloreCTal cancer, and screening colonoscopy guidelines should be revised in the familial-risk population.
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Lynch-like syndrome is as frequent as Lynch syndrome in early-onset nonfamilial nonpolyposis colorectal cancer.
Marina Antelo,Mariano Golubicki,Enrique Roca,Guillermo Mendez,Marcela Carballido,Soledad Iseas,Miriam Cuatrecasas,Leticia Moreira,Ariadna Sánchez,Sabela Carballal,Antoni Castells,Clement Richard Boland,Ajay Goel,Francesc Balaguer +13 more
TL;DR: It is found that 20% of patients with EO NP NF CRC have MMRd tumors, and at least half of these are likely to have LLS.
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Lymph node pooling: a feasible and efficient method of lymph node molecular staging in colorectal carcinoma.
Natalia Rakislova,Carla Montironi,Iban Aldecoa,Eva Fernández,Josep Antoni Bombí,Mireya Jimeno,Francesc Balaguer,Maria Pellise,Antoni Castells,Miriam Cuatrecasas +9 more
TL;DR: LN pooling makes it possible to analyze a high number of LNs from surgical colectomies with few molecular tests per patient and provides a more accurate LN pathological staging with potential prognostic implications.
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Germline biallelic Mcm8 variants are associated with early-onset Lynch-like syndrome
Mariano Golubicki,Laia Bonjoch,José G. Acuña-Ochoa,Marcos Díaz-Gay,Jenifer Muñoz,Miriam Cuatrecasas,Teresa Ocaña,Soledad Iseas,Guillermo Mendez,Daniel Cisterna,Stephanie A. Schubert,Maartje Nielsen,Tom van Wezel,Yael Goldberg,Eli Pikarsky,Juan Robbio,Enrique Roca,Antoni Castells,Francesc Balaguer,Marina Antelo,Sergi Castellví-Bel +20 more
TL;DR: MCM8 is suggested as a gene involved in CRC germline predisposition with a recessive pattern of inheritance and microsatellite instability and mutational signatures in MCM8KO cells were compatible with the involvement of MCM 8 in MMR.
Journal ArticleDOI
Association of the ARLTS1 Cys148Arg variant with sporadic and familial colorectal cancer.
Sergi Castellví-Bel,Antoni Castells,Rafael de Cid,Jenifer Muñoz,Francesc Balaguer,Victoria Gonzalo,Clara Ruiz-Ponte,Montserrat Andreu,Xavier Llor,Rodrigo Jover,Xavier Bessa,Rosa M. Xicola,Elisenda Pons,Cristina Alenda,Artemio Payá,Angel Carracedo,Josep M. Piqué +16 more
TL;DR: C148R did show, for the first time in CRC, statistically significant differences between cases and controls, in agreement with a hypothetical moderate increase of the cancer risk linked to the C148R ARLTS1 variant, both in sporadic and familial CRC cases.