D
Domenico Paparella
Researcher at University of Bari
Publications - 143
Citations - 4724
Domenico Paparella is an academic researcher from University of Bari. The author has contributed to research in topics: Cardiopulmonary bypass & Medicine. The author has an hindex of 28, co-authored 124 publications receiving 3878 citations. Previous affiliations of Domenico Paparella include University Hospital of Basel & University of Toronto.
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Journal ArticleDOI
Cardiopulmonary bypass induced inflammation: pathophysiology and treatment. An update
TL;DR: Emphasis is given to the central role of transcription factor NF-kappa B in the complex mechanism of the inflammatory reaction and to the effects of compounds such as heparin and glycosaminoglycans, phosphodiesterase inhibitors and protease inhibitors whose role as anti-inflammatory agent has only recently been recognized.
Journal ArticleDOI
Association between driving pressure and development of postoperative pulmonary complications in patients undergoing mechanical ventilation for general anaesthesia: a meta-analysis of individual patient data.
Ary Serpa Neto,Sabrine N.T. Hemmes,Carmen Silvia Valente Barbas,Martin Beiderlinden,Ana Fernandez-Bustamante,Emmanuel Futier,Ognjen Gajic,Mohamed R. El-Tahan,Abdulmohsin A.Al Ghamdi,Ersin Günay,Samir Jaber,Serdar Kokulu,Alf Kozian,Marc Licker,Wen Qian Lin,Andrew Maslow,Stavros G. Memtsoudis,Dinis dos Reis Miranda,Pierre Moine,Thomas Ng,Domenico Paparella,V. Marco Ranieri,V. Marco Ranieri,Federica Scavonetto,Thomas F. Schilling,Gabriele Selmo,Paolo Severgnini,Juraj Sprung,Sugantha Sundar,Daniel Talmor,Tanja A. Treschan,Carmen Unzueta,Toby N. Weingarten,Esther K. Wolthuis,Hermann Wrigge,Marcelo B. P. Amato,Eduardo L. V. Costa,Marcelo Gama de Abreu,Paolo Pelosi,Marcus J. Schultz +39 more
TL;DR: In patients having surgery, intraoperative high driving pressure and changes in the level of PEEP that result in an increase of driving pressure are associated with more postoperative pulmonary complications, and a randomised controlled trial comparing ventilation based on driving pressure with usual care is needed to confirm these findings.
Journal ArticleDOI
Coagulation disorders of cardiopulmonary bypass: a review.
TL;DR: A better comprehension of the multifactorial mechanisms of activation of coagulation, inflammation, and fibrinolytic pathways during CPB may enable a more effective use of the technical and pharmaceutical options which are currently available.
Journal ArticleDOI
Protective versus Conventional Ventilation for Surgery: A Systematic Review and Individual Patient Data Meta-analysis
Ary Serpa Neto,Ary Serpa Neto,Sabrine N.T. Hemmes,Carmen Silvia Valente Barbas,Martin Beiderlinden,Michelle Biehl,Jan M. Binnekade,Jaume Canet,Ana Fernandez-Bustamante,Emmanuel Futier,Ognjen Gajic,Göran Hedenstierna,Markus W. Hollmann,Samir Jaber,Alf Kozian,Marc Licker,Wen Qian Lin,Andrew Maslow,Stavros G. Memtsoudis,Dinis dos Reis Miranda,Pierre Moine,Thomas Ng,Domenico Paparella,Christian Putensen,Marco Ranieri,Federica Scavonetto,Thomas F. Schilling,Werner Schmid,Gabriele Selmo,Paolo Severgnini,Juraj Sprung,Sugantha Sundar,Daniel Talmor,Tanja A. Treschan,Carmen Unzueta,Toby N. Weingarten,Esther K. Wolthuis,Hermann Wrigge,Marcelo Gama de Abreu,Paolo Pelosi,Marcus J. Schultz +40 more
TL;DR: These data support the beneficial effects of ventilation with use of low VT in patients undergoing surgery and the role of intraoperative higher PEEP to prevent PPC during nonopen abdominal surgery.
Journal ArticleDOI
Methylprednisolone in patients undergoing cardiopulmonary bypass (SIRS): A randomised, double-blind, placebo-controlled trial
Richard P. Whitlock,Richard P. Whitlock,Philip J. Devereaux,Philip J. Devereaux,Kevin Teoh,Andre Lamy,Andre Lamy,Jessica Vincent,Janice Pogue,Domenico Paparella,Daniel I. Sessler,Ganesan Karthikeyan,Juan Carlos Villar,Yunxia Zuo,Alvaro Avezum,Mackenzie A. Quantz,Georgios I Tagarakis,Pallav Shah,Seyed Hesameddin Abbasi,Hong Zheng,Shirley Pettit,Susan Chrolavicius,Salim Yusuf,Salim Yusuf +23 more
TL;DR: Methylprednisolone did not have a significant effect on mortality or major morbidity after cardiac surgery with cardiopulmonary bypass and the SIRS trial does not support the routine use of methylprednisOLone for patients undergoing cardiopULmonary bypass.