F
Francesca Mingozzi
Researcher at University of Milano-Bicocca
Publications - 12
Citations - 486
Francesca Mingozzi is an academic researcher from University of Milano-Bicocca. The author has contributed to research in topics: Immune system & Innate immune system. The author has an hindex of 5, co-authored 10 publications receiving 401 citations.
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Journal ArticleDOI
CD14 regulates the dendritic cell life cycle after LPS exposure through NFAT activation
Ivan Zanoni,Renato Ostuni,Giusy Capuano,Maddalena Collini,Michele Caccia,Antonella Ronchi,Marcella Rocchetti,Francesca Mingozzi,Maria Foti,Giuseppe Chirico,Barbara Costa,Antonio Zaza,Paola Ricciardi-Castagnoli,Paola Ricciardi-Castagnoli,Francesca Granucci +14 more
TL;DR: It is shown that mouse dendritic cell stimulation with lipopolysaccharide (LPS) induces Src-family kinase and phospholipase Cγ2 activation, influx of extracellular Ca2+ and calcineurin-dependent nuclear NFAT translocation, and LPS-induced NFAT activation via CD14 is necessary to cause the apoptotic death of terminally differentiateddendritic cells.
Journal ArticleDOI
Migratory, and not lymphoid-resident, dendritic cells maintain peripheral self-tolerance and prevent autoimmunity via induction of iTreg cells.
Caterina Vitali,Francesca Mingozzi,Achille Broggi,Simona Barresi,Francesca Zolezzi,Jagadeesh Bayry,Giorgio Raimondi,Ivan Zanoni,Francesca Granucci +8 more
TL;DR: It is shown that, when autoantigen presentation is extended to all conventional mouse DCs, immature lymphoid tissue resident DCs are unable to induceAutoantigen-specific regulatory T (iTreg) cell conversion, which is an exclusive prerogative of steady-state migratory DCs.
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Engineered Ferritin Nanoparticles for the Bioluminescence Tracking of Nanodrug Delivery in Cancer
Michela Bellini,Benedetta Riva,Veronica Tinelli,Maria Antonietta Rizzuto,Lucia Salvioni,Miriam Colombo,Francesca Mingozzi,Alberto Visioli,Laura Marongiu,Gianni Frascotti,Michael S. Christodoulou,Daniele Passarella,Davide Prosperi,Luisa Fiandra +13 more
TL;DR: The prolonged imaging of luciferase+ tumor models, demonstrated by an in vitro and an in vivo approach, associated with the prolonged release ofLuciferin into cancer cells by disulfide bridge reduction, clearly indicates the high efficiency of Luc-linker@HFn for drug delivery to the tumor tissues.
Journal ArticleDOI
Prolonged contact with dendritic cells turns lymph node‐resident NK cells into anti‐tumor effectors
Francesca Mingozzi,Roberto Spreafico,Tatiana Gorletta,Clara Cigni,Marco Di Gioia,Michele Caccia,Laura Sironi,Maddalena Collini,Matias Cristobal Soncini,Michela Rusconi,Ulrich H. von Andrian,Ulrich H. von Andrian,Giuseppe Chirico,Ivan Zanoni,Ivan Zanoni,Francesca Granucci +15 more
TL;DR: It is shown that upon triggering innate immunity with lipopolysaccharide (LPS), NK cells are transiently activated, leave the lymph node, and infiltrate the tumor, delaying its growth.
Journal ArticleDOI
Skin infections are eliminated by cooperation of the fibrinolytic and innate immune systems
William Santus,Simona Barresi,Francesca Mingozzi,Achille Broggi,Ivan Orlandi,Giulia Stamerra,Marina Vai,Alessandra M. Martorana,Alessandra Polissi,Julia R. Köhler,Ning-Ning Liu,Ivan Zanoni,Ivan Zanoni,Francesca Granucci +13 more
TL;DR: This work shows that early activation of NFAT balances the two major phases of the innate response to Candida albicans skin infections: the protective containment and the elimination phases.