S
Simona Barresi
Researcher at University of Milano-Bicocca
Publications - 8
Citations - 978
Simona Barresi is an academic researcher from University of Milano-Bicocca. The author has contributed to research in topics: Innate immune system & Inflammation. The author has an hindex of 5, co-authored 7 publications receiving 803 citations. Previous affiliations of Simona Barresi include University of Milan.
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Journal ArticleDOI
CD14 Controls the LPS-Induced Endocytosis of Toll-like Receptor 4
Ivan Zanoni,Renato Ostuni,Lorri R. Marek,Simona Barresi,Roman Barbalat,Gregory M. Barton,Francesca Granucci,Jonathan C. Kagan +7 more
TL;DR: It is reported that the plasma membrane localized Pattern Recognition Receptor (PRR) CD14 is required for the microbe-induced endocytosis of TLR4, and this innate immune trafficking cascade illustrates how pathogen detection systems operate to induce both membrane transport and signal transduction.
Journal ArticleDOI
Migratory, and not lymphoid-resident, dendritic cells maintain peripheral self-tolerance and prevent autoimmunity via induction of iTreg cells.
Caterina Vitali,Francesca Mingozzi,Achille Broggi,Simona Barresi,Francesca Zolezzi,Jagadeesh Bayry,Giorgio Raimondi,Ivan Zanoni,Francesca Granucci +8 more
TL;DR: It is shown that, when autoantigen presentation is extended to all conventional mouse DCs, immature lymphoid tissue resident DCs are unable to induceAutoantigen-specific regulatory T (iTreg) cell conversion, which is an exclusive prerogative of steady-state migratory DCs.
Journal ArticleDOI
CD14 and NFAT mediate lipopolysaccharide-induced skin edema formation in mice
Ivan Zanoni,Renato Ostuni,Simona Barresi,Marco Di Gioia,Achille Broggi,Barbara Costa,Roberta Marzi,Francesca Granucci +7 more
TL;DR: It is shown that tissue-resident DCs are the main source of PGE2 and the main controllers of tissue edema formation in a mouse model of LPS-induced inflammation, suggesting that the CD14/NFAT/mPGES-1 pathway represents a possible target for antiinflammatory therapies.
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Cellular and transcriptional dynamics of human neutrophils at steady state and upon stress
Elisa Montaldo,Eleonora Lusito,Valentina Bianchessi,Nicoletta Caronni,Serena Scala,Luca Basso-Ricci,Carla Cantaffa,Alice Masserdotti,Mattia Barilaro,Simona Barresi,Marco Genua,F. M. Vittoria,Giulia Barbiera,Dejan Lazarevic,Carlo Messina,Elisabetta Xue,Sarah Marktel,Cristina Tresoldi,Raffaella Milani,Paola Ronchi,Salvatore Gattillo,Luca Santoleri,Raffaella Di Micco,Andrea Ditadi,Giulio Belfiori,Francesca Aleotti,Matteo M. Naldini,Bernhard Gentner,Elisa Gardiman,Nicola Tamassia,Marco A. Cassatella,Andrés Hidalgo,Immanuel Kwok,Lai Guan Ng,Stefano Crippa,Massimo Falconi,Francesca Pettinella,Patrizia Scapini,Luigi Naldini,Fabio Ciceri,Alessandro Aiuti,Renato Ostuni +41 more
TL;DR: Ostuni et al. as discussed by the authors performed immunophenotypic and transcriptome analysis to characterize the heterogeneity of human neutrophils, both under steady state and upon stress-induced conditions.
Journal ArticleDOI
Skin infections are eliminated by cooperation of the fibrinolytic and innate immune systems
William Santus,Simona Barresi,Francesca Mingozzi,Achille Broggi,Ivan Orlandi,Giulia Stamerra,Marina Vai,Alessandra M. Martorana,Alessandra Polissi,Julia R. Köhler,Ning-Ning Liu,Ivan Zanoni,Ivan Zanoni,Francesca Granucci +13 more
TL;DR: This work shows that early activation of NFAT balances the two major phases of the innate response to Candida albicans skin infections: the protective containment and the elimination phases.