F
Francesca Piccioli
Researcher at University of Florence
Publications - 14
Citations - 636
Francesca Piccioli is an academic researcher from University of Florence. The author has contributed to research in topics: Ruthenium & Serum albumin. The author has an hindex of 13, co-authored 14 publications receiving 602 citations.
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Journal ArticleDOI
Biological role of adduct formation of the ruthenium(III) complex NAMI-A with serum albumin and serum transferrin.
TL;DR: The present results suggest that binding to plasma proteins causes a drastic decrease of NAMI-A bioavailability and a subsequent reduction of its biological activity, implying that association to Plasma proteins essentially represents a mechanism of drug inactivation.
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A comparative study of adduct formation between the anticancer ruthenium(III) compound HInd trans-[RuCl4(Ind)2] and serum proteins
Francesca Piccioli,S. Sabatini,Luigi Messori,Pierluigi Orioli,C. G. Hartinger,Bernard K. Keppler +5 more
TL;DR: Formation of adducts between the antitumor ruthenium(III) complex [HInd]trans-[RuCl(4)(Ind)(2)] (KP1019) and the plasma proteins serum albumin and serum transferrin was investigated by UV-vis spectroscopy, for metal-to-protein ratios ranging from 1:1 to 5:1.
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Antiangiogenic properties of selected ruthenium(III) complexes that are nitric oxide scavengers
Lucia Morbidelli,Sandra Donnini,Sandra Filippi,Luigi Messori,Francesca Piccioli,Pierluigi Orioli,Gianni Sava,Marina Ziche +7 more
TL;DR: The key steps of angiogenesis, endothelial cell proliferation and migration stimulated by vascular endothelial growth factor or NO donor drugs, were blocked by NAMI-A, KP1339 and RuEDTA, these compounds being devoid of any cytotoxic activity.
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Copper and zinc dismetabolism in the mouse brain upon chronic cuprizone treatment.
Paolo Zatta,Michelangelo Raso,Pamela Zambenedetti,W. Wittkowski,Luigi Messori,Francesca Piccioli,Pierluigi Mauri,Mariano Beltramini +7 more
TL;DR: In this paper, the authors used cuprizone, a very sensitive and selective copper-chelating agent with well-known neurotoxic properties, as a relevant chemical model in mice.
Journal ArticleDOI
Decomposition of ascorbic acid in the presence of cadmium ions leads to formation of a polymeric cadmium oxalate species with peculiar structural features.
TL;DR: Slow decomposition of L-ascorbic acid, carried out under aerobic conditions and in the presence of cadmium ions, results in formation of a crystalline product that is highly insoluble in water.