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Nguan Soon Tan
Researcher at Nanyang Technological University
Publications - 224
Citations - 12679
Nguan Soon Tan is an academic researcher from Nanyang Technological University. The author has contributed to research in topics: Peroxisome proliferator-activated receptor & Receptor. The author has an hindex of 53, co-authored 204 publications receiving 10611 citations. Previous affiliations of Nguan Soon Tan include Institute of Molecular and Cell Biology & University of Lausanne.
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Journal ArticleDOI
Characterization of the Fasting-induced Adipose Factor FIAF, a Novel Peroxisome Proliferator-activated Receptor Target Gene
Sander Kersten,Stéphane Mandard,Nguan Soon Tan,Pascal Escher,Daniel Metzger,Pierre Chambon,Frank J. Gonzalez,Béatrice Desvergne,Walter Wahli +8 more
TL;DR: The data suggest that FIAF represents a novel endocrine signal involved in the regulation of metabolism, especially under fasting conditions, and is strongly up-regulated by fasting in white adipose tissue and liver.
Journal ArticleDOI
Selective Cooperation between Fatty Acid Binding Proteins and Peroxisome Proliferator-Activated Receptors in Regulating Transcription
Nguan Soon Tan,Natacha S. Shaw,Natacha S. Shaw,Nicolas Vinckenbosch,Nicolas Vinckenbosch,Peng Liu,Peng Liu,Rubina Yasmin,Rubina Yasmin,Béatrice Desvergne,Béatrice Desvergne,Walter Wahli,Walter Wahli,Noa Noy,Noa Noy +14 more
TL;DR: The data demonstrate that the presence of high levels of K-FABP in keratinocytes is essential for PPARβ-mediated induction of differentiation of these cells, thereby enabling PPARs to exert their biological functions.
Journal ArticleDOI
Impaired skin wound healing in peroxisome proliferator–activated receptor (PPAR)α and PPARβ mutant mice
Liliane Michalik,Béatrice Desvergne,Nguan Soon Tan,Sharmila Basu-Modak,Pascal Escher,Jennifer Rieusset,Jeffrey M. Peters,Gürkan Kaya,Frank J. Gonzalez,Jozsef Zakany,Daniel Metzger,Pierre Chambon,Denis Duboule,Walter Wahli +13 more
TL;DR: The findings presented here reveal unpredicted roles for PPARα and β in adult mouse epidermal repair and PPARβ mutant primary keratinocytes show impaired adhesion and migration properties.
Journal ArticleDOI
Critical roles of PPARβ/δ in keratinocyte response to inflammation
Nguan Soon Tan,Liliane Michalik,Noa Noy,Noa Noy,Rubina Yasmin,Corinne Pacot,Corinne Pacot,Manuel Heim,Beat Flühmann,Béatrice Desvergne,Walter Wahli +10 more
TL;DR: It is shown, by use of cultures of primary keratinocytes from wild-type and PPAR/ �/� mice, that such signals including TNF- and IFN-, induce keratinocyte differentiation and this effect is also observed in vivo during wound healing after an injury.
Journal ArticleDOI
Titanium dioxide nanomaterials cause endothelial cell leakiness by disrupting the homophilic interaction of VE–cadherin
Magdiel Inggrid Setyawati,Chor Yong Tay,S L Chia,S L Goh,Wanru Fang,M J Neo,Han Chung Chong,S M Tan,Say Chye Joachim Loo,Kee Woei Ng,Jianping Xie,Choon Nam Ong,Nguan Soon Tan,Nguan Soon Tan,David Tai Leong +14 more
TL;DR: It is shown that injections of TiO₂ nanomaterials cause leakiness of subcutaneous blood vessels in mice and, in a melanoma-lung metastasis mouse model, increase the number of pulmonary metastases.