Franco Cardone

TL;DR: In this paper, a comparison of clinical and neuropathologic diagnoses and evaluation of the sensitivity and specificity of EEG and 14-3-3 CSF immunoassay were conducted.

TL;DR: The efficiency of primary transmission of prions from Creutzfeldt–Jakob disease patients to a wild rodent species, the bank vole, is comparable to that reported in transgenic mice carrying human prion protein, in spite of a lowPrion protein–sequence homology between man and vole.

TL;DR: The effectiveness of the PMCA technology to detect the protease‐resistance disease‐associated prion protein (PrPres) in pre‐symptomatic stages indicates that PMCA may be useful for the development of an ultra‐sensitive diagnostic test to minimize the risk of further propagation of TSEs.

TL;DR: In this paper, the authors examined peripheral regions of the olfactory sensory pathway, including the Olfactory mucosa, to assess whether pathologic infectious prion protein (PrPSc) is deposited in the epithelium lining the nasal cavity.

TL;DR: In sporadic CJD patients, high CSF levels of PGE2, but not 8-epi-PGF2α, correlated with short survival time, suggesting that the inflammatory response correlates with the clinical duration of disease.