N. Delasnerie-Laupretre

TL;DR: In this paper, a comparison of clinical and neuropathologic diagnoses and evaluation of the sensitivity and specificity of EEG and 14-3-3 CSF immunoassay were conducted.

TL;DR: The authors' results show that clinicopathological phenotypes include genetic Creutzfeldt–Jakob disease (gCJD), fatal familial insomnia (FFI), and Gerstmann–Sträussler–Scheinker disease (GSS).

TL;DR: Overall epidemiologic characteristics for Creutzfeldt–Jakob disease (CJD) of all types in a multinational population–based study are established and the occurrence of a novel form of human bovine spongiform encephalopathy infection other than variant CJD is not suggested.

TL;DR: In sporadic disease, longer survival was correlated with younger age at onset of illness, female gender, codon 129 heterozygosity, presence of CSF 14-3-3 protein and type 2a prion protein type, and the characterization of the survival distributions, in the absence of therapy, will be an important starting point for the assessment of potential therapeutic agents in the future.

TL;DR: The statistical data reported here do not provide evidence of a causal link between BSE and CJD in Europe as a whole, however, the study has established baseline epidemiological parameters for CJd in participating European countries, which may be important in the assessment of any future change in the characteristics of CJD.