F
François Rouyer
Researcher at Pasteur Institute
Publications - 12
Citations - 1576
François Rouyer is an academic researcher from Pasteur Institute. The author has contributed to research in topics: Pseudoautosomal region & X chromosome. The author has an hindex of 10, co-authored 12 publications receiving 1566 citations.
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Journal ArticleDOI
A Deletion Map of the Human Y Chromosome Based on DNA Hybridization
Gilles Vergnaud,David C. Page,Marie-Christine Simmler,Laura J. E. Brown,François Rouyer,Bernard Noel,David Botstein,Albert de la Chapelle,Jean Weissenbach +8 more
Journal Article
A deletion map of the human Y chromosome based on DNA hybridization.
Gilles Vergnaud,David C. Page,Marie-Christine Simmler,L.G. Brown,François Rouyer,Bernard Noel,David Botstein,de la Chapelle A,Jean Weissenbach +8 more
TL;DR: The results suggest a deletion map of the Y chromosome, in which each of the 23 Y-specific restriction fragments tested can be assigned to one of seven intervals, and the polarity of this map with respect to the long and short arms of theY chromosome is established.
Journal ArticleDOI
A gradient of sex linkage in the pseudoautosomal region of the human sex chromosomes.
François Rouyer,Marie-Christine Simmler,Christophe Johnsson,Gilles Vergnaud,Howard J. Cooke,Jean Weissenbach +5 more
TL;DR: Three independent pseudoautosomal loci are linked to sex determination at frequencies which define a gradient of linkage that indicates that X/Y recombination results from a single obligatory meiotic crossing-over in the pseudoautOSomal region.
Journal ArticleDOI
Pseudoautosomal DNA sequences in the pairing region of the human sex chromosomes.
Marie-Christine Simmler,François Rouyer,Gilles Vergnaud,Minna Nyström-Lahti,Kim Yen Ngo,Albert de la Chapelle,Jean Weissenbach +6 more
TL;DR: A DNA probe from a human Y chromosome-derived cosmid detects a single-copy genomic DNA fragment which can appear in different allelic forms shared by both sex chromosomes, and variations at this DNA locus show an autosomal pattern of inheritance, undergo recombination with sexual phenotype and can be described as ‘pseudoautosomal’.
Journal ArticleDOI
A sex chromosome rearrangement in a human XX male caused by Alu-Alu recombination.
TL;DR: This work proposes that this XX male arose by abnormal crossing over between DXYS5 on the Y chromosome and a pseudoautosomal locus on the X chromosome during paternal meiosis, and sequence analysis of the junction shows that homologous recombination occurred between two Alu sequences from these otherwise nonhomologous regions.