Journal ArticleDOI
A Deletion Map of the Human Y Chromosome Based on DNA Hybridization
Gilles Vergnaud,David C. Page,Marie-Christine Simmler,Laura J. E. Brown,François Rouyer,Bernard Noel,David Botstein,Albert de la Chapelle,Jean Weissenbach +8 more
About:
This article is published in Obstetrical & Gynecological Survey.The article was published on 1986-10-01. It has received 341 citations till now. The article focuses on the topics: Chromosome 21 & Chromosome 22.read more
Citations
More filters
Journal ArticleDOI
A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif
Andrew H. Sinclair,Berta P,Berta P,M. S. Palmer,Hawkins,B. Griffiths,Smith Mj,Foster Jw,Foster Jw,A.-M. Frischauf,Robin Lovell-Badge,Peter N. Goodfellow +11 more
TL;DR: A search of a 35-kilobase region of the human Y chromosome necessary for male sex determination has resulted in the identification of a new gene, termed SRY (for sex-determining region Y) and proposed to be a candidate for the elusive testis-d determining gene, TDF.
Journal ArticleDOI
The sex-determining region of the human Y chromosome encodes a finger protein
David C. Page,Rebecca Mosher,Elizabeth M. Simpson,Elizabeth M. C. Fisher,Graeme Mardon,Jonathan R. Pollack,Barbara McGillivray,Albert de la Chapelle,Laura G. Brown +8 more
TL;DR: The possibility that the Y-encoded finger protein is the testis-determining factor is discussed, and models of sex determination accommodating the finding of a related locus on the X chromosome are proposed.
Journal ArticleDOI
A Y chromosome gene family with RNA-binding protein homology: Candidates for the azoospermia factor AZF controlling human spermatogenesis
Kun Ma,John D. Inglis,Andrew M. Sharkey,Wendy A. Bickmore,Robert E. Hill,E.Jane Prosser,R. M. Speed,Eric J. Thomson,Mark A. Jobling,K Taylor,Jonathan Wolfe,Jonathan Wolfe,Howard J. Cooke,Timothy B. Hargreave,Ann C. Chandley +14 more
TL;DR: The isolation and characterization of a gene family located within a deletion in Y chromosome interval 6 is reported, suggesting a possible role in RNA processing or translational control during early spermatogenesis.
Journal ArticleDOI
The human Y chromosome: a 43-interval map based on naturally occurring deletions.
Douglas Vollrath,Simon Foote,Adrienne Hilton,Laura G. Brown,Peggy Beer-Romero,Jonathan S. Bogan,David C. Page +6 more
TL;DR: A deletion map of the human Y chromosome was constructed by testing 96 individuals with partial Y chromosomes for the presence or absence of many DNA loci, and should be useful in identifying Y chromosomal genes, in exploring the origin of chromosomal disorders, and in tracing the evolution of the Y chromosome.
Journal ArticleDOI
Y chromosome microdeletions and alterations of spermatogenesis.
TL;DR: A clear correlation exists between the size and localization of the deletions and the testicular phenotype, however, it is clear that larger deletions are associated with the most severe testicular damage.
References
More filters
Journal ArticleDOI
Detection of specific sequences among DNA fragments separated by gel electrophoresis.
TL;DR: This paper describes a method of transferring fragments of DNA from agarose gels to cellulose nitrate filters that can be hybridized to radioactive RNA and hybrids detected by radioautography or fluorography.
Analysis of human Y-chromosome-specific reiterated DNA in
L. M. Kunkel,Kirby D. Smith,Samuel H. Boye,Digamber S. Borgaonkar,W. Roy Breg,Howard W. Jones,Jack M. Raryt +6 more
TL;DR: A number of individuals with aberrant Y chromosomes have been tested for the presence of Y-chromo-some-specific reiterated DNA as discussed by the authors, which represents at least 10% of Y chromosome DNA.
Journal ArticleDOI
X-y chromosomal interchange in the ætiology of true hermaphroditism and of xx klinefelter's syndrome
Journal ArticleDOI
Y-encoded, species-specific DNA in mice: Evidence that the Y chromosome exists in two polymorphic forms in inbred strains
Ellen E. Lamar,Edward Palmer +1 more
TL;DR: Examination of polymorphic Y chromosome restriction fragments in male DNA from nine different inbred strains suggests that only two polymorphic forms of Y chromosomal DNA exist among inbreeding strains of mice.