Françoise Gosselin

TL;DR: A reliable prenatal diagnosis of congenital CMV infection based on PCR on amniocentesis samples can be made after 21 weeks' pregnancy, after a 7-week interval between diagnosis of maternal infection and antenatal procedure.

TL;DR: It is demonstrated here that restricted Vγ9Vδ2 cells with preprogrammed effector function represent the predominant γδ T-cell subset circulating in human fetal blood, suggesting that, despite developing in a sterile environment, the human fetal γ Δ T cell repertoire is enriched for pathogen-reactive T cells well before pathogen exposure.

TL;DR: In this article, it was shown that the human fetal thymus generates invariant TCRs with programmed effector functions, and that both the generation of invariant and intrathymic acquisition of effector function were due to an intrinsic property of fetal hematopoietic stem and precursor cells (HSPCs) caused by high expression of the RNA-binding protein Lin28b.

TL;DR: It is demonstrated that the generation of a fetal-type or adult-type Vγ9Vδ2 CDR3 repertoire is determined by the fetal and postnatal nature of the hematopoietic stem and precursor cell.