F
Frank Baas
Researcher at Leiden University Medical Center
Publications - 446
Citations - 33815
Frank Baas is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Gene & Complement system. The author has an hindex of 93, co-authored 434 publications receiving 31187 citations. Previous affiliations of Frank Baas include Flanders Institute for Biotechnology & Academic Medical Center.
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Journal ArticleDOI
Germline SMARCB1 mutation and somatic NF2 mutations in familial multiple meningiomas
I Christiaans,S B Kenter,H C Brink,T.A.M. van Os,Frank Baas,P. van den Munckhof,A M J Kidd,Theo J. M. Hulsebos +7 more
TL;DR: A four-hit mechanism of tumour suppressor gene inactivation, involving SMARCB1 and NF2, might be operative in familial multiple meningiomas associated mening iomas.
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Statistical evaluation of SAGE libraries: consequences for experimental design
TL;DR: A comparison showed that, for SAGE libraries of equal as well as different size, SAGE300, Fisher's Exact test, Z test, and the Audic and Claverie test have critical values within 1.5% of each other, which indicates that these four tests will give essentially the same results when applied to Sage libraries.
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Utilization of unlocked nucleic acid (UNA) to enhance siRNA performance in vitro and in vivo
Maria B. Laursen,Maria B. Laursen,Malgorzata M. Pakula,Shan Gao,Kees Fluiter,Olaf R.F. Mook,Frank Baas,Niels Langklær,Suzy L. Wengel,Jesper Wengel,Jørgen Kjems,Jesper B. Bramsen +11 more
TL;DR: The destabilizing properties of UNA are well suited to enhance the potency of siRNAs which are heavily modified by other chemical modifications such as locked nucleic acid (LNA), C4'hydroxymethyl-DNA (HM), 2'-O-methyl-RNA (OMe), DNA and 2'-Flouro-DNA
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Allelotype of pediatric rhabdomyosarcoma
Mike Visser,Carin Sijmons,Johannes Bras,Robert J. Arceci,Mark Godfried,Linda J. Valentijn,P.A. Voûte,Frank Baas +7 more
TL;DR: The data suggest that genes involved in the development of RMS and WT may not only be similar for chromosome 11 but also for chromosome 16, and that LOH of chromosome 16 is also found in other tumors, including WT.
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Germline SMARCB1 mutation predisposes to multiple meningiomas and schwannomas with preferential location of cranial meningiomas at the falx cerebri.
TL;DR: It is concluded that the SMARCB1 exon 2 missense mutation in this family predisposes to the development of meningiomas as well as schwannomas, occurring via the same genetic pathways, and that this mutation preferentially induces cranial meningIomas located at the falx cerebri.