F
Frank Gerlach
Researcher at University of Hamburg
Publications - 16
Citations - 1183
Frank Gerlach is an academic researcher from University of Hamburg. The author has contributed to research in topics: Cytoglobin & Neuroglobin. The author has an hindex of 14, co-authored 16 publications receiving 1132 citations. Previous affiliations of Frank Gerlach include University of Mainz.
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Journal ArticleDOI
Neuroglobin and cytoglobin in search of their role in the vertebrate globin family.
Thomas Hankeln,Bettina Ebner,Christine Fuchs,Frank Gerlach,Mark Haberkamp,Tilmann Laufs,Anja Roesner,Marc Schmidt,Bettina Weich,Sylvia Wystub,Sigrid Saaler-Reinhardt,Stefan Reuss,Martino Bolognesi,Daniele de Sanctis,Michael C. Marden,Laurent Kiger,Luc Moens,Sylvia Dewilde,Eviatar Nevo,Aaron Avivi,Roy E. Weber,Angela Fago,Thorsten Burmester +22 more
TL;DR: Present evidence points to an important role of neuroglobin in neuronal oxygen homeostasis and hypoxia protection, though other functions are still conceivable, as first glimpse into the possible physiological roles of these globins in the animal's metabolism.
Journal ArticleDOI
Cytoglobin is a respiratory protein in connective tissue and neurons, which is up-regulated by hypoxia.
Marc Schmidt,Frank Gerlach,Aaron Avivi,Tilmann Laufs,Sylvia Wystub,Jeremy C. Simpson,Eviatar Nevo,Sigrid Saaler-Reinhardt,Stefan Reuss,Thomas Hankeln,Thorsten Burmester +10 more
TL;DR: The differential expression of cytoglobin argues against a general respiratory function of this molecule, but rather indicates a connective tissue-specific function and it is hypothesized that cytoglobin may be involved in collagen synthesis.
Journal ArticleDOI
Neuroglobin, cytoglobin, and myoglobin contribute to hypoxia adaptation of the subterranean mole rat Spalax
Aaron Avivi,Frank Gerlach,Alma Joel,Stefan Reuss,Thorsten Burmester,Eviatar Nevo,Thomas Hankeln +6 more
TL;DR: The data suggest that tissue globins contribute to the remarkable tolerance of Spalax toward environmental hypoxia, consistent with the proposed cytoprotective effect of Ngb and Cygb under pathological hypoxic/ischemic conditions in mammals.
Journal ArticleDOI
Neuroglobin and cytoglobin : Genes, proteins and evolution
Thorsten Burmester,Mark Haberkamp,Stephanie Mitz,Anja Roesner,Marc Schmidt,Bettina Ebner,Frank Gerlach,Christine Fuchs,Thomas Hankeln +8 more
TL;DR: The pattern of globin evolution shows that proteins with clear respiratory roles evolved independently from intracellular globins with uncertain functions, which suggests either multiple independent functional changes or a yet undefined respiratory role of tissue globins like Ngb and Cygb.
Book ChapterDOI
Regulation and role of neuroglobin and cytoglobin under hypoxia.
TL;DR: Data suggest that Ngb may have a myoglobin-like role and supplies oxygen to the respiratory chain of the metabolically highly active neurons, or protect them from reactive oxygen species.