F
Frank Martinez
Researcher at Necker-Enfants Malades Hospital
Publications - 101
Citations - 4902
Frank Martinez is an academic researcher from Necker-Enfants Malades Hospital. The author has contributed to research in topics: Transplantation & Kidney transplantation. The author has an hindex of 32, co-authored 96 publications receiving 4085 citations. Previous affiliations of Frank Martinez include Paris Descartes University & Sorbonne.
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Journal ArticleDOI
Recessive mutations in DGKE cause atypical hemolytic-uremic syndrome
Mathieu Lemaire,Véronique Frémeaux-Bacchi,Franz Schaefer,Murim Choi,Wai Ho Tang,Moglie Le Quintrec,Fadi Fakhouri,Sophie Taque,François Nobili,Frank Martinez,Weizhen Ji,John D. Overton,Shrikant Mane,Gudrun Nürnberg,Janine Altmüller,Holger Thiele,Denis Morin,Georges Deschênes,Véronique Baudouin,Brigitte Llanas,Laure Collard,Mohammed Abdul Majid,Eva Simkova,Peter Nürnberg,Nathalie Rioux-Leclerc,Gilbert W. Moeckel,Marie Claire Gubler,John Hwa,Chantal Loirat,Richard P. Lifton +29 more
TL;DR: Using exome sequencing, it is inferred that loss of DGKE function results in a prothrombotic state, identifying a new mechanism of pathologic thrombosis and kidney failure and have immediate implications for treating individuals with aHUS.
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Tenofovir-Related Nephrotoxicity in Human Immunodeficiency Virus-Infected Patients: Three Cases of Renal Failure, Fanconi Syndrome, and Nephrogenic Diabetes Insipidus
Alexandre Karras,Matthieu Lafaurie,André Furco,Anne Bourgarit,Dominique Droz,Daniel Sereni,Christophe Legendre,Frank Martinez,Jean-Michel Molina +8 more
TL;DR: Renal failure, proximal tubular dysfunction, and nephrogenic diabetes insipidus were observed, and, in 2 cases, renal biopsy revealed severe tubular necrosis with characteristic nuclear changes.
Journal ArticleDOI
Targeted therapy in patients with PIK3CA-related overgrowth syndrome
Quitterie Venot,Thomas Blanc,Thomas Blanc,Thomas Blanc,Smail Hadj Rabia,Smail Hadj Rabia,Laureline Berteloot,Sophia Ladraa,J P Duong,J P Duong,Estelle Blanc,Simon C. Johnson,Clément Hoguin,Olivia Boccara,Sabine Sarnacki,Sabine Sarnacki,Nathalie Boddaert,Nathalie Boddaert,Stéphanie Pannier,Stéphanie Pannier,Frank Martinez,Sato Magassa,Junna Yamaguchi,Bertrand Knebelmann,Bertrand Knebelmann,Bertrand Knebelmann,Pierre Merville,Nicolas Grenier,Dominique Joly,Dominique Joly,Dominique Joly,Valérie Cormier-Daire,Valérie Cormier-Daire,Caroline Michot,Caroline Michot,Christine Bole-Feysot,Arnaud Picard,Arnaud Picard,Véronique Soupre,Stanislas Lyonnet,Stanislas Lyonnet,Jérémy Sadoine,Lotfi Slimani,Catherine Chaussain,Cécile Laroche-Raynaud,Laurent Guibaud,Christine Broissand,Jeanne Amiel,Jeanne Amiel,Christophe Legendre,Christophe Legendre,Christophe Legendre,Fabiola Terzi,Fabiola Terzi,Guillaume Canaud,Guillaume Canaud,Guillaume Canaud +56 more
TL;DR: This study provides the first direct evidence supporting PIK3CA inhibition as a promising therapeutic strategy in patients with PROS, by reversing symptoms in a mouse model of PROS/CLOVES syndrome, which results from gain-of-function mutations in PI3KCA.
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Subclinical Rejection Phenotypes at 1 Year Post-Transplant and Outcome of Kidney Allografts
Alexandre Loupy,Dewi Vernerey,Claire Tinel,Olivier Aubert,Jean-Paul Duong Van Huyen,Marion Rabant,Jérôme Verine,Dominique Nochy,Jean-Philippe Empana,Frank Martinez,Denis Glotz,Xavier Jouven,Christophe Legendre,Carmen Lefaucheur +13 more
TL;DR: It is suggested that subclinical TCMR and subclinical ABMR have distinct effects on long-term graft loss, and only those who further developed de novo donor-specific antibodies and transplant glomerulopathy showed higher risk of graft loss compared with patients without rejection.
Journal ArticleDOI
Factors influencing long-term outcome after kidney transplantation.
TL;DR: Although current immunosuppression regimes are highly efficient in preventing acute rejection, the burden of specific (diabetes, nephrotoxicity) and nonspecific side effects has significant negative long‐term consequences that may well be worse in the future because of the increasing ages of both donors and recipients.