L
Laurent Guibaud
Researcher at HCL Technologies
Publications - 11
Citations - 1009
Laurent Guibaud is an academic researcher from HCL Technologies. The author has contributed to research in topics: Clinical trial & Volume of distribution. The author has an hindex of 6, co-authored 11 publications receiving 681 citations.
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Journal ArticleDOI
A Randomized, Controlled Trial of Oral Propranolol in Infantile Hemangioma
Christine Léauté-Labrèze,Peter H. Hoeger,Juliette Mazereeuw-Hautier,Laurent Guibaud,Eulalia Baselga,Gintas Posiunas,Roderic J Phillips,Héctor Cáceres,Juan Carlos López Gutiérrez,Rosalia Ballona,Sheila Fallon Friedlander,Julie Powell,Danuta Perek,Brandie J. Metz,Sébastien Barbarot,Annabel Maruani,Zsuzsanna Szalai,Alfons Krol,Olivia Boccara,Regina Foelster-Holst,María Isabel Febrer Bosch,John C Su,Hana Buckova,Antonio Torrelo,Frédéric Cambazard,Rainer Grantzow,Orli Wargon,Dariusz Wyrzykowski,Jochen Roessler,Jose Bernabeu-Wittel,Adriana M Valencia,Przemysław Przewratil,Sharon A. Glick,Elena Pope,Nicholas Birchall,Latanya Benjamin,Anthony J. Mancini,Pierre Vabres,Pierre Souteyrand,Ilona J. Frieden,Charles I Berul,Cyrus R. Mehta,Sorilla Prey,Franck Boralevi,Caroline C. Morgan,Stephane Heritier,Alain Delarue,Jean-Jacques Voisard +47 more
TL;DR: This trial showed that propranolol was effective at a dose of 3 mg per kilogram per day for 6 months in the treatment of infantile hemangioma.
Journal ArticleDOI
Targeted therapy in patients with PIK3CA-related overgrowth syndrome
Quitterie Venot,Thomas Blanc,Thomas Blanc,Thomas Blanc,Smail Hadj Rabia,Smail Hadj Rabia,Laureline Berteloot,Sophia Ladraa,J P Duong,J P Duong,Estelle Blanc,Simon C. Johnson,Clément Hoguin,Olivia Boccara,Sabine Sarnacki,Sabine Sarnacki,Nathalie Boddaert,Nathalie Boddaert,Stéphanie Pannier,Stéphanie Pannier,Frank Martinez,Sato Magassa,Junna Yamaguchi,Bertrand Knebelmann,Bertrand Knebelmann,Bertrand Knebelmann,Pierre Merville,Nicolas Grenier,Dominique Joly,Dominique Joly,Dominique Joly,Valérie Cormier-Daire,Valérie Cormier-Daire,Caroline Michot,Caroline Michot,Christine Bole-Feysot,Arnaud Picard,Arnaud Picard,Véronique Soupre,Stanislas Lyonnet,Stanislas Lyonnet,Jérémy Sadoine,Lotfi Slimani,Catherine Chaussain,Cécile Laroche-Raynaud,Laurent Guibaud,Christine Broissand,Jeanne Amiel,Jeanne Amiel,Christophe Legendre,Christophe Legendre,Christophe Legendre,Fabiola Terzi,Fabiola Terzi,Guillaume Canaud,Guillaume Canaud,Guillaume Canaud +56 more
TL;DR: This study provides the first direct evidence supporting PIK3CA inhibition as a promising therapeutic strategy in patients with PROS, by reversing symptoms in a mouse model of PROS/CLOVES syndrome, which results from gain-of-function mutations in PI3KCA.
Journal ArticleDOI
Outcome of isolated agenesis of the corpus callosum: A population-based prospective study.
Vincent des Portes,A. Rolland,Juan Velazquez-Dominguez,Emeline Peyric,Marie-Pierre Cordier,Pascal Gaucherand,Jérôme Massardier,Mona Massoud,Aurore Curie,Anne-Sophie Pellot,François Rivier,Audrey Lacalm,Amélie Clément,Dorothée Ville,Laurent Guibaud +14 more
TL;DR: The data indicate that intellectual ability is normal (IQ > 85) in approximately two thirds and borderline in just over a quarter of patients, however, a low risk of severe cognitive impairment exists, and this information should be shared with couples during prenatal counselling.
Journal ArticleDOI
Ultrasound examination of the antrum to predict gastric content volume in the third trimester of pregnancy as assessed by MRI: A prospective cohort study
Mathilde Roukhomovsky,Laurent Zieleskiewicz,Alexandre Diaz,Laurent Guibaud,Kathia Chaumoitre,François-Pierrick Desgranges,Marc Leone,Dominique Chassard,Lionel Bouvet,CAR’Echo Collaborative Networks AzuRea +9 more
TL;DR: A new mathematical model predictive of GCV in women in the third trimester of pregnancy is reported and the combination of the qualitative and the quantitative ultrasound examination of the gastric antrum might be useful to assess gastric fluid volume in pregnant women.
Journal ArticleDOI
Alpelisib administration reduced lymphatic malformations in a mouse model and in patients.
Florence Delestre,Florence Delestre,Quitterie Venot,Quitterie Venot,Charles Bayard,Charles Bayard,Antoine Fraissenon,Antoine Fraissenon,Sophia Ladraa,Sophia Ladraa,Clément Hoguin,Clément Hoguin,Célia Chapelle,Célia Chapelle,Junna Yamaguchi,Junna Yamaguchi,Rubina Cassaca,Rubina Cassaca,Lola Zerbib,Lola Zerbib,Sato Magassa,Sato Magassa,Gabriel Morin,Gabriel Morin,Vahid Asnafi,Vahid Asnafi,Patrick Villarese,Sophie Kaltenbach,Sophie Kaltenbach,Sylvie Fraitag,J. Duong,J. Duong,Christine Broissand,Olivia Boccara,Véronique Soupre,Bernard Bonnotte,Caroline Chopinet,Tristan Mirault,Christophe Legendre,Christophe Legendre,Laurent Guibaud,Guillaume Canaud +41 more
TL;DR: Lymphatic cystic malformations are rare genetic disorders mainly due to somatic gain-of-function mutations in the PIK3CA gene as discussed by the authors, these anomalies are frequently associated with pain, inflammatory flar...