Y
Yui-Hsi Wang
Researcher at Cincinnati Children's Hospital Medical Center
Publications - 43
Citations - 8262
Yui-Hsi Wang is an academic researcher from Cincinnati Children's Hospital Medical Center. The author has contributed to research in topics: Thymic stromal lymphopoietin & Mast cell. The author has an hindex of 27, co-authored 41 publications receiving 7564 citations. Previous affiliations of Yui-Hsi Wang include University of Texas MD Anderson Cancer Center.
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Journal ArticleDOI
Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide.
Roberto Lande,Josh Gregorio,Valeria Facchinetti,Bithi Chatterjee,Bithi Chatterjee,Yi Hong Wang,Bernhard Homey,Wei Cao,Yui-Hsi Wang,Bing Su,Frank O. Nestle,Tomasz Zal,Ira Mellman,Ira Mellman,Jens-Michael Schröder,Yong-Jun Liu,Michel Gilliet +16 more
TL;DR: The data uncover a fundamental role of an endogenous antimicrobial peptide in breaking innate tolerance to self-DNA and suggest that this pathway may drive autoimmunity in psoriasis.
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TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand
Tomoki Ito,Yui-Hsi Wang,Omar Duramad,Omar Duramad,Toshiyuki Hori,Guy Delespesse,Norihiko Watanabe,F. Xiao Feng Qin,Zhengbin Yao,Wei Cao,Yong-Jun Liu,Yong-Jun Liu +11 more
TL;DR: It is proposed that OX40L on TSLP-activated DCs triggers Th2 cell polarization in the absence of IL-12, and can switch IL-10–producing regulatory Th cell responses into TNF-α–producing inflammatory Th cell responds.
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Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus.
TL;DR: It is reported that human Hassall's corpuscles express thymic stromal lymphopoietin (TSLP), indicating a critical role in dendritic-cell-mediated secondary positive selection of medium-to-high affinity self-reactive T cells, leading to the generation of CD4+CD25+ regulatory T cells within the thymus.
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IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC–activated Th2 memory cells
Yui-Hsi Wang,Pornpimon Angkasekwinai,Pornpimon Angkasekwinai,Pornpimon Angkasekwinai,Ning Lu,Kui Shin Voo,Kazuhiko Arima,Shino Hanabuchi,Andreas Hippe,Christopher Corrigan,Chen Dong,Bernhard Homey,Zhengbin Yao,Sun Ying,David P. Huston,Yong-Jun Liu,Yong-Jun Liu +16 more
TL;DR: The results provide a plausible explanation that IL-25 produced by innate effector eosinophils and basophils may augment the allergic inflammation by enhancing the maintenance and functions of adaptive Th2 memory cells.
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TSLP: An Epithelial Cell Cytokine that Regulates T Cell Differentiation by Conditioning Dendritic Cell Maturation
Yong-Jun Liu,Vasilli Soumelis,Norihiko Watanabe,Tomoki Ito,Yui-Hsi Wang,Rene De Waal Malefyt,Miyuki Omori,Baohua Zhou,Steven F. Ziegler +8 more
TL;DR: Recent studies of TSLP (thymic stromal lymphopoietin), an epithelial cell-derived cytokine that strongly activates DCs, provide evidence at a molecular level that epithelial cells/tissue microenvironments directly communicate with DCs.