F
Frank R. DeLeo
Researcher at National Institutes of Health
Publications - 210
Citations - 28910
Frank R. DeLeo is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Staphylococcus aureus & Innate immune system. The author has an hindex of 86, co-authored 206 publications receiving 26462 citations. Previous affiliations of Frank R. DeLeo include Montana State University & University of Iowa.
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Journal ArticleDOI
Transient Association of the Nicotinamide Adenine Dinucleotide Phosphate Oxidase Subunits p47phox and p67phox With Phagosomes in Neutrophils From Patients With X-Linked Chronic Granulomatous Disease
Lee-Ann H. Allen,Frank R. DeLeo,Frank R. DeLeo,Frank R. DeLeo,Annabelle Gallois,Annabelle Gallois,Annabelle Gallois,Satoshi Toyoshima,Satoshi Toyoshima,Satoshi Toyoshima,Kensuke Suzuki,Kensuke Suzuki,Kensuke Suzuki,William M. Nauseef,William M. Nauseef,William M. Nauseef +15 more
TL;DR: Examination of the association of cytosolic NADPH oxidase subunits with phagosomes containing opsonized zymosan supports a model in which flavocytochrome b is required for stable membrane binding of p47phox and p67phox, but not their association with the cytoskeleton or transport to the cell periphery.
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A domain of p47phox that interacts with human neutrophil flavocytochrome b558.
Frank R. DeLeo,William M. Nauseef,Algirdas J. Jesaitis,James B. Burritt,Robert A. Clark,Mark T. Quinn +5 more
TL;DR: Synthetic peptides inhibited membrane association of p47phox in the broken cell translocation assay and O∸2 production by electropermeabilized neutrophils, thereby supporting the interpretation that this region of p 47phox interacts with flavocytochrome b.
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A Chemokine-Degrading Extracellular Protease Made by Group A Streptococcus Alters Pathogenesis by Enhancing Evasion of the Innate Immune Response
Paul Sumby,Shizhen Zhang,Adeline R. Whitney,Fabiana Falugi,Guido Grandi,Edward A. Graviss,Frank R. DeLeo,James M. Musser +7 more
TL;DR: It is demonstrated that the group A Streptococcus (GAS) protease SpyCEP cleaves granulocyte chemotactic protein 2 and growth-related oncogene alpha (GROα), two potent chemokines made abundantly in human tonsils.
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Identification and Characterization of HtsA, a Second Heme-Binding Protein Made by Streptococcus pyogenes
Benfang Lei,Mengyao Liu,Jovanka M. Voyich,Christopher I. Prater,Subbarao V. Kala,Frank R. DeLeo,James M. Musser +6 more
TL;DR: It is suggested that HtsABC is an ABC transporter that may participate in heme acquisition in GAS, and was produced in vitro and localized to the bacterial cell surface.
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Central role of a bacterial two-component gene regulatory system of previously unknown function in pathogen persistence in human saliva
Samuel A. Shelburne,Paul Sumby,Paul Sumby,Izabela Sitkiewicz,Izabela Sitkiewicz,Chanel Granville,Frank R. DeLeo,James M. Musser,James M. Musser +8 more
TL;DR: It is concluded that SptR/S optimizes persistence of GAS in human saliva, apparently by strategically influencing metabolic pathways and virulence factor production.