F
Frank Robledo-Avila
Researcher at Nationwide Children's Hospital
Publications - 25
Citations - 423
Frank Robledo-Avila is an academic researcher from Nationwide Children's Hospital. The author has contributed to research in topics: Immune system & Cystic fibrosis. The author has an hindex of 10, co-authored 21 publications receiving 248 citations. Previous affiliations of Frank Robledo-Avila include Instituto Politécnico Nacional & Ohio State University.
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Journal ArticleDOI
Caspase-11 Mediates Neutrophil Chemotaxis and Extracellular Trap Formation During Acute Gouty Arthritis Through Alteration of Cofilin Phosphorylation.
Kyle Caution,Nicholas A. Young,Frank Robledo-Avila,Kathrin Krause,Arwa Abu Khweek,Arwa Abu Khweek,Kaitlin Hamilton,Asmaa Badr,Anup Vaidya,Kylene Daily,Hawin Gosu,Midhun N. K. Anne,Mostafa Eltobgy,Duaa Dakhlallah,Sudha Argwal,Shady Estfanous,Xiaoli Zhang,Santiago Partida-Sanchez,Mikhail A. Gavrilin,Wael N. Jarjour,Amal O. Amer +20 more
TL;DR: It is shown that caspase-11−/− mice and their derived macrophages produce significantly reduced levels of gout-specific cytokines including IL-1β, TNFα, IL-6, and KC, while others like IFNγ and IL-12p70 are not altered.
Journal ArticleDOI
Z-form extracellular DNA is a structural component of the bacterial biofilm matrix
John R. Buzzo,Aishwarya Devaraj,Erin S. Gloag,Joseph A. Jurcisek,Frank Robledo-Avila,Theresa Kesler,Kathryn Wilbanks,Lauren Mashburn-Warren,Sabarathnam Balu,Joseph Wickham,Laura A. Novotny,Paul Stoodley,Paul Stoodley,Lauren O. Bakaletz,Lauren O. Bakaletz,Steven D. Goodman,Steven D. Goodman +16 more
TL;DR: In this article, the role of Z-DNA in biofilm pathogenesis, innate immune response, and immune evasion was investigated and it was shown that the universal bacterial DNABII family of proteins stabilizes both bacterial and host eDNA in the Z-form in situ.
Journal ArticleDOI
Dysregulated Calcium Homeostasis in Cystic Fibrosis Neutrophils Leads to Deficient Antimicrobial Responses.
Frank Robledo-Avila,Juan de Dios Ruiz-Rosado,Kenneth L. Brockman,Benjamin T. Kopp,Benjamin T. Kopp,Amal O. Amer,Karen McCoy,Karen McCoy,Lauren O. Bakaletz,Lauren O. Bakaletz,Santiago Partida-Sanchez +10 more
TL;DR: It is suggested that regulation of neutrophil Ca2+ homeostasis (via CFTR potentiation or by the regulation ofCa2+ channels) can be used as a new therapeutic approach for reestablishing immune function in patients with CF.
Journal ArticleDOI
Human Cystic Fibrosis Macrophages Have Defective Calcium-Dependent Protein Kinase C Activation of the NADPH Oxidase, an Effect Augmented by Burkholderia cenocepacia.
Kaivon Assani,Chandra L. Shrestha,Frank Robledo-Avila,Murugesan V. S. Rajaram,Santiago Partida-Sanchez,Larry S. Schlesinger,Benjamin T. Kopp +6 more
TL;DR: Analysis of CF and non-CF human monocyte-derived macrophages for ROS production, NADPH assembly capacity, protein kinase C expression, and calcium release in response to PMA and CF pathogens implicate a critical role for defective macrophage oxidative responses in persistent bacterial infections in CF.
Journal ArticleDOI
Whole-blood transcriptomic responses to lumacaftor/ivacaftor therapy in cystic fibrosis
Benjamin T. Kopp,James Fitch,Lisa Jaramillo,Chandra L. Shrestha,Frank Robledo-Avila,Shuzhong Zhang,Sabrina Palacios,Fred Woodley,Don Hayes,Santiago Partida-Sanchez,Octavio Ramilo,Peter White,Asuncion Mejias +12 more
TL;DR: In this paper, a whole-blood transcriptomics was performed using RNA-Seq in 20 patients with CF pre-and 6 months post-lumacaftor/ivacaftors (drug) initiation and 20 non-CF healthy controls.