F
Frank Staib
Researcher at University of Mainz
Publications - 21
Citations - 1631
Frank Staib is an academic researcher from University of Mainz. The author has contributed to research in topics: Carcinogenesis & Tumor suppressor gene. The author has an hindex of 13, co-authored 21 publications receiving 1501 citations. Previous affiliations of Frank Staib include National Institutes of Health.
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Journal ArticleDOI
TP53 mutations and hepatocellular carcinoma: insights into the etiology and pathogenesis of liver cancer
TL;DR: In summary, both viruses and chemicals are implicated in the etiology of TP53 mutations during the molecular pathogenesis of HCC.
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TP53 and liver carcinogenesis.
TL;DR: Both viruses and chemicals are implicated in the etiology and molecular pathogenesis of HCC, with the resultant molecular changes in the ras and Wnt signal‐transduction pathways, and the p53 and Rb tumor suppressor pathways significantly contribute to liver carcinogenesis.
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Different efficiency of heat shock proteins (HSP) to activate human monocytes and dendritic cells: superiority of HSP60.
Karen Bethke,Frank Staib,Martin Distler,Ute Schmitt,Helmut Jonuleit,Alexander Enk,Peter R. Galle,Michael Heike +7 more
TL;DR: Findings show that HSP can differ considerably in the capacity to activate monocyte-derived APC under certain conditions and underline the potential of HSP60 and HSP72 as activation signals for the innate immune system.
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Adaptive immunity suppresses formation and progression of diethylnitrosamine-induced liver cancer
Carlo Schneider,Andreas Teufel,Tetyana Yevsa,Frank Staib,Anja Hohmeyer,Gudrun Walenda,Henning W. Zimmermann,Mihael Vucur,Sebastian Huss,Nikolaus Gassler,Hermann E. Wasmuth,Sergio A. Lira,Lars Zender,Tom Luedde,Christian Trautwein,Frank Tacke +15 more
TL;DR: Distinct axes of the adaptive immune system, which are also prognostic in human HCC, actively suppress DEN-induced hepatocarcinogenesis by controlling tumour formation and progression.
Journal ArticleDOI
Genetics of hepatocellular carcinoma.
Andreas Teufel,Frank Staib,Stephan Kanzler,Arndt Weinmann,Henning Schulze-Bergkamen,Peter R. Galle +5 more
TL;DR: The genetics and regulation of major signalling pathways involved in HCC such as p53, Wnt-signalling, TGFbeta, Ras, and Rb pathways are described and the influence of chromosomal aberrations as well as of DNA methylation is described.