F
Franz-Josef Kaup
Researcher at German Primate Center
Publications - 96
Citations - 1839
Franz-Josef Kaup is an academic researcher from German Primate Center. The author has contributed to research in topics: Simian immunodeficiency virus & Virus. The author has an hindex of 23, co-authored 96 publications receiving 1708 citations. Previous affiliations of Franz-Josef Kaup include University of Göttingen.
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Journal ArticleDOI
Molecular Cloning and Expression of Major Structural Protein VP1 of the Human Polyomavirus JC Virus: Formation of Virus-Like Particles Useful for Immunological and Therapeutic Studies
Claudia Goldmann,Harald Petry,Stephan A. Frye,Oliver Ast,Susanne Ebitsch,Klaus-dieter Jentsch,Franz-Josef Kaup,Frank Weber,Corinna Trebst,Nisslein T,Gerhard Hunsmann,Thomas Weber,Wolfgang Lüke +12 more
TL;DR: The major structural viral protein, VP1, of the human polyomavirus JC virus, the causative agent of progressive multifocal leukoencephalopathy (PML), was expressed by using recombinant baculoviruses and the potential of VP1 VLP as an efficient transporter system for gene therapy was demonstrated.
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Animal model for the therapy of acquired immunodeficiency syndrome with reverse transcriptase inhibitors.
Klaus Überla,Christiane Stahl-Hennig,D Böttiger,K. Mätz-Rensing,Franz-Josef Kaup,J Li,W A Haseltine,Bernhard Fleckenstein,Gerhard Hunsmann,B Oberg +9 more
TL;DR: Infection of macaques with the chimeric virus seems to be a valuable model to study the in vivo efficacy of new RT inhibitors, the emergence and reversal of drug resistance, the therapy of infections with drug-resistant viruses, and the efficacy of combination therapy.
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Association of simian immunodeficiency virus Nef with cellular serine/threonine kinases is dispensable for the development of AIDS in rhesus macaques
Sabine Lang,A. J. Iafrate,Christiane Stahl-Hennig,Eva M. Kuhn,Nisslein T,Franz-Josef Kaup,Haupt M,Gerhard Hunsmann,Jacek Skowronski,Frank Kirchhoff +9 more
TL;DR: The findings indicate that the putative SH3-ligand domain in SIVmac Nef and the association with cellular serine/threonine kinases are not important for efficient replication and pathogenicity of SIV Mac in rhesus macaques.
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Rapid development of vaccine protection in macaques by live-attenuated simian immunodeficiency virus.
Stahl-Hennig C,Dittmer U,Nisslein T,Harald Petry,Jurkiewicz E,Dietmar Fuchs,H. Wachter,Kerstin Mätz-Rensing,Eva M. Kuhn,Franz-Josef Kaup,Erling W. Rud,Gerhard Hunsmann +11 more
TL;DR: A sterilizing immunity against superinfection with pathogenic SIV can be induced even after a relatively short waiting period of 22 weeks, Nevertheless, such a vaccine raises severe safety concerns because of its potential to revert to virulence.
Journal ArticleDOI
Fatal Poxvirus Outbreak in a Colony of New World Monkeys
Kerstin Mätz-Rensing,H. Ellerbrok,Bernhard Ehlers,G. Pauli,A. Floto,M. Alex,C.-P. Czerny,Franz-Josef Kaup +7 more
TL;DR: An epizootic infection was observed in a colony of 80 New World monkeys consisting of various species including a group of marmosets and Saguinus species, and phylogenetic analyses revealed closest homology to cowpox viruses.