Sabine Lang

TL;DR: It is shown that moderate mtDNA stress elicited by TFAM deficiency engages cytosolic antiviral signalling to enhance the expression of a subset of interferon-stimulated genes, and it is suggested that cellular monitoring of mtDNA homeostasis cooperates with canonical virus sensing mechanisms to fully engage antiviral innate immunity.

TL;DR: A defective c-Mpl expression due to c-mpl mutations is proposed as the cause for thrombocytopenia and progression into pancy topenia seen in patients with CAMT.

TL;DR: The first preclinical in vitro and in vivo comparison of GA101 (obinutuzumab), a novel glycoengineered type II CD20 monoclonal antibody, with rituximab and ofatumumab, the two currently approved type I CD20 antibodies was reported in this article.

TL;DR: These findings identify an important determinant of the SIVpbj14 phenotype, and they provide evidence of a role for nef in signal transduction and cellular activation.

TL;DR: Results indicate that vpr provides only a slight facilitating advantage for wild-type SIVmac replication in vivo, and progression to AIDS and death can occur in the absence of a gene for vpr or vpx.