F
Fred N. Ross-Cisneros
Researcher at University of California, Los Angeles
Publications - 65
Citations - 4064
Fred N. Ross-Cisneros is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Optic neuropathy & Retinal ganglion. The author has an hindex of 25, co-authored 64 publications receiving 3507 citations. Previous affiliations of Fred N. Ross-Cisneros include University of Southern California.
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Journal ArticleDOI
Mitochondrial dysfunction as a cause of optic neuropathies
TL;DR: The recent identification of mutations in the nuclear gene OPA1 as the causative factor in dominant optic atrophy (DOA) brought the unexpected finding that this gene encodes for a mitochondrial protein, suggesting that DOA and LHON may be linked by similar pathogenesis.
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Melanopsin retinal ganglion cell loss in Alzheimer disease
Chiara La Morgia,Fred N. Ross-Cisneros,Yosef Koronyo,Jens Hannibal,Roberto Gallassi,Gaetano Cantalupo,Luisa Sambati,Billy X. Pan,Kevin R. Tozer,Piero Barboni,Federica Provini,Pietro Avanzini,Michele Carbonelli,Annalisa Pelosi,Helena C. Chui,Rocco Liguori,Agostino Baruzzi,Maya Koronyo-Hamaoui,Alfredo A. Sadun,Valerio Carelli +19 more
TL;DR: This work investigated mRGCs in AD, hypothesizing that they contribute to circadian dysfunction, and confirmed their role in photoreceptors driving circadian photoentraining.
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Optic nerve degeneration and mitochondrial dysfunction: genetic and acquired optic neuropathies.
TL;DR: Biochemical and cellular studies in LHON point to a partial defect of respiratory chain function that may generate either an ATP synthesis defect and/or a chronic increase of oxidative stress, possibly affecting the oligodendrocytes of the optic nerves.
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Efficient mitochondrial biogenesis drives incomplete penetrance in Leber's hereditary optic neuropathy.
Carla Giordano,Luisa Iommarini,Luca Giordano,Alessandra Maresca,Annalinda Pisano,Maria Lucia Valentino,Leonardo Caporali,Rocco Liguori,Stefania Deceglie,Marina Roberti,Francesca Fanelli,Flavio Fracasso,Fred N. Ross-Cisneros,Pio D'Adamo,Gavin Hudson,Angela Pyle,Patrick Yu-Wai-Man,Patrick F. Chinnery,Massimo Zeviani,Solange Rios Salomão,Adriana Berezovsky,Rubens Belfort,Dora Fix Ventura,Milton Rocha Moraes,Milton Moraes Filho,Piero Barboni,Federico Sadun,Annamaria De Negri,Alfredo A. Sadun,Andrea Tancredi,Massimiliano Mancini,Giulia d'Amati,Paola Loguercio Polosa,Palmiro Cantatore,Valerio Carelli +34 more
TL;DR: Giordano et al. show that mitochondrial DNA content and mitochondrial mass are both increased in tissues and cells from unaffected mutation carriers relative to affected relatives and control individuals, suggesting upregulation of mitochondrial biogenesis may represent a therapeutic target.
Journal ArticleDOI
Oestrogens ameliorate mitochondrial dysfunction in Leber’s hereditary optic neuropathy
Carla Giordano,Monica Montopoli,Elena Perli,Maurizia Orlandi,Marianna Fantin,Fred N. Ross-Cisneros,Laura Caparrotta,Andrea Martinuzzi,Eugenio Ragazzi,Anna Ghelli,Alfredo A. Sadun,Giulia d'Amati,Valerio Carelli +12 more
TL;DR: A metabolic basis for the unexplained male prevalence in Leber's hereditary optic neuropathy is supported and promises for a therapeutic use for oestrogen-like molecules are held and it is shown that the oestrogens receptor β localizes to the mitochondrial network of human retinal ganglion cells.